Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model
- Authors
- Kim, Byeong-Gon; Lee, Pureun-Haneul; Lee, Shin-Hwa; Kim, Young-En; Shin, Mee-Yong; Kang, Yena; Bae, Seong-Hwan; Kim, Min-Jung; Rhim, TaiYoun; Park, Choon-Sik; Jang, An-Soo
- Issue Date
- May-2016
- Publisher
- 대한천식알레르기학회
- Keywords
- Chronic; diesel exhaust particles; airway remodeling
- Citation
- Allergy, Asthma & Immunology Research, v.8, no.3, pp 246 - 256
- Pages
- 11
- Journal Title
- Allergy, Asthma & Immunology Research
- Volume
- 8
- Number
- 3
- Start Page
- 246
- End Page
- 256
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9167
- DOI
- 10.4168/aair.2016.8.3.246
- ISSN
- 2092-7355
2092-7363
- Abstract
- Purpose: Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model. Methods: BALB/c mice were exposed to DEPs 1 hour a day for 5 days a week for 3 months in a closed-system chamber attached to a ultrasonic nebulizer (low dose: 100 mu g/m(3) DEPs, high dose: 3 mg/m(3) DEPs). The control group was exposed to saline. Enhanced pause was measured as an indicator of AHR. Animals were subjected to whole-body plethysmography and then sacrificed to determine the performance of bronchoalveolar lavage and histology. Results: AHR was higher in the DEP group than in the control group, and higher in the high-dose DEP than in the low-dose DEP groups at 4, 8, and 12 weeks. The numbers of neutrophils and lymphocytes were higher in the high-dose DEP group than in the low-dose DEP group and control group at 4, 8, and 12 weeks. The levels of interleukin (IL)-5, IL-13, and interferon-gamma were higher in the low-dose DEP group than in the control group at 12 weeks. The level of IL-10 was higher in the high-dose DEP group than in the control group at 12 weeks. The level of vascular endothelial growth factor was higher in the low-dose and high-dose DEP groups than in the control group at 12 weeks. The level of IL-6 was higher in the low-dose DEP group than in the control group at 12 weeks. The level of transforming growth factor-beta was higher in the high-dose DEP group than in the control group at 4, 8, and 12 weeks. The collagen content and lung fibrosis in lung tissue was higher in the high-dose DEP group at 8 and 12 weeks. Conclusions: These results suggest that long-term DEP exposure may increase AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Pediatrics > 1. Journal Articles
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