Comparison of motor and non-motor features between essential tremor and tremor dominant Parkinson's disease
- Authors
- Kwon, Kyum-Yil; Lee, Hye Mi; Lee, Seon-Min; Kang, Sung Hoon; Koh, Seong-Beom
- Issue Date
- 15-Feb-2016
- Publisher
- Elsevier BV
- Keywords
- Parkinson's disease; Tremor dominant; Essential tremor; non-motor symptom; Surface electromyogram
- Citation
- Journal of the Neurological Sciences, v.361, pp 34 - 38
- Pages
- 5
- Journal Title
- Journal of the Neurological Sciences
- Volume
- 361
- Start Page
- 34
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9350
- DOI
- 10.1016/j.jns.2015.12.016
- ISSN
- 0022-510X
1878-5883
- Abstract
- Background: Differential diagnosis of tremor disorders, including essential tremor (ET) and Parkinson's disease tremor dominant type (PD-TDT), requires further investigation. Therefore, the current study aimed to compare non-motor and tremor features in order to differentiate between ET and PD-TDT. Methods: Twenty-eight patients with classic ET and 24 patients with typical PD-TDT were retrospectively enrolled in a multi-stage investigation process. Tremor features including surface electromyogram (EMG) were analyzed in detail. For non-motor symptom analyses, the global cognition test, frontal function test, and non-motor symptoms scale (NMSS) were administered, in addition to collecting patient history data. Results: Patients with PD-TDT presented with more asymmetric tremor, whereas patients with ET presented with more symmetric tremor. Leg tremor was observed only in patients with PD-TDT. Surface EMG analyses of arm tremor demonstrated considerable overlaps in tremor type, tremor frequency, and contractive patterns. However, patients with PD-TDT were significantly more likely to exhibit resting tremor, and experienced alternative contraction patterns only for kinetic tremor, which was in contrast to patients with ET. For non-motor symptom analyses, patients with PD-TDT had more non-motor symptoms compared to patients with ET (mean = 5.0 vs. 2.6; P = 0.002). Specifically, patients with PD-TDT exhibited higher frequencies of hyposmia, REM sleep behavior disorder (RBD)-like symptom, urinary frequency, and memory disturbance. Age- and gender-matched analyses for the severity of NMSS scores did not indicate significant differences. However, patients with PD-TDT displayed slightly lower scores of frontal function test compared to patients with ET. Conclusions: Careful and detailed evaluations of both tremor features and non-motor symptoms are required in order to distinguish between ET and PD-TDT. (C) 2015 Elsevier B.V. All rights reserved.
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