Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review
- Authors
- Bae, Sung Hwan; Hwang, Jung Hwa; Nam, Bo Da; Kim, Hyun Jo; Kim, Ki-Up; Kim, Dong Won; Choi, In Ho
- Issue Date
- Feb-2016
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review
- Citation
- Medicine, v.95, no.7
- Journal Title
- Medicine
- Volume
- 95
- Number
- 7
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9384
- DOI
- 10.1097/MD.0000000000002725
- ISSN
- 0025-7974
1536-5964
- Abstract
- Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are high-grade malignant neoplasms. These malignancies present very rare tumors of thoracopulmonary area and even rarer in the mediastinum. In our knowledge, ES/PNET presented with multiple mediastinal masses has not been reported previously.We experienced a case of a 42-year-old man presented with gradual onset of left-side pleuritic chest pain. A contrast-enhanced chest computed tomography (CT) scan showed separate 2 large heterogeneously enhancing masses in each anterior and middle mediastinum of the left hemithorax. Positron emission tomography-computed tomography (PET-CT) scan revealed high fluorodeoxyglucose (FDG) uptake in the mediastinal masses. After surgical excision for the mediastinal masses, both of the masses were diagnosed as the ES/PNET group of tumors on the histopathologic examination. The patient refused postoperative adjuvant chemotherapy and came back with local tumor recurrence and distant metastasis on 4-month follow-up after surgical resection.We report this uncommon form of ES/PNET. We are to raise awareness that this rare malignancy should be considered as a differential diagnosis of the malignant mediastinal tumors and which can be manifested as multiple masses in a patient. Understanding this rare entity of extra-skeletal ES/PNET and characteristic imaging findings can help radiologists and clinicians to approach proper diagnosis and better management for this highly malignant tumor.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Cardiovascular Surgery > 1. Journal Articles
- College of Medicine > Department of Radiology > 1. Journal Articles
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