Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Jung, Chan-Hee | - |
dc.contributor.author | Kim, Kyu-Jin | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kang, Sung Koo | - |
dc.contributor.author | Mok, Ji-Oh | - |
dc.date.accessioned | 2021-08-11T18:24:00Z | - |
dc.date.available | 2021-08-11T18:24:00Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9393 | - |
dc.description.abstract | We aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) and microvascular complications in type 2 diabetes mellitus (T2DM) patients. It was hypothesized that lower 25(OH)D would be associated with increased microvascular complications in T2DM. A total of 257 T2DM patients (111 men, 146 women) who underwent diabetic microvascular complication (peripheral neuropathy, nephropathy, retinopathy) studies were recruited. Patients were categorized into 3 groups according to vitamin D status: vitamin D sufficient (n = 41, 25[OH]D >= 20 ng/mL), vitamin D insufficient (n = 132, 10 <= 25[OH]D < 20 ng/mL), and vitamin D deficient (n = 84, 25[OH]D < 10 ng/mL). In men, the prevalence of diabetic peripheral neuropathy (DPN) was significantly higher in patients with vitamin D deficiency than in those with insufficiency or sufficiency (38%, 11.7%, and 10%, respectively; P = .005). In addition, the prevalence of diabetic nephropathy (DN) was significantly higher in women with vitamin D deficiency than in the other 2 groups (40%, 20.6%, and 0%; P = .007). Compared with men in the vitamin D-sufficient group (reference), men in the vitamin D-deficient group had an increased risk of DPN after adjusting for confounding factors (odds ratio, 7.79; 95% confidence interval, 1.52-40.05). For women, when the vitamin D-sufficient group was used as a reference, those in the vitamin D-deficient group had an increased risk of DN after adjusting for confounding factors (odds ratio, 4.27; 95% confidence interval, 1.58-11.56). This present study found that a serum 25(OH)D level less than 10 ng/mL is independently associated with increased DPN in male patients and increased DN in female patients with T2DM. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.nutres.2015.11.008 | - |
dc.identifier.scopusid | 2-s2.0-84958048585 | - |
dc.identifier.wosid | 000369776800002 | - |
dc.identifier.bibliographicCitation | Nutrition Research, v.36, no.2, pp 117 - 124 | - |
dc.citation.title | Nutrition Research | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 124 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | PERIPHERAL NEUROPATHY | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INSUFFICIENCY | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Peripheral neuropathy | - |
dc.subject.keywordAuthor | Nephropathy | - |
dc.subject.keywordAuthor | Microvascular complication | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
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