Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus
- Authors
- Jung, Chan-Hee; Kim, Kyu-Jin; Kim, Bo-Yeon; Kim, Chul-Hee; Kang, Sung Koo; Mok, Ji-Oh
- Issue Date
- Feb-2016
- Publisher
- Elsevier BV
- Keywords
- Vitamin D; Peripheral neuropathy; Nephropathy; Microvascular complication; Type 2 diabetes mellitus
- Citation
- Nutrition Research, v.36, no.2, pp 117 - 124
- Pages
- 8
- Journal Title
- Nutrition Research
- Volume
- 36
- Number
- 2
- Start Page
- 117
- End Page
- 124
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9393
- DOI
- 10.1016/j.nutres.2015.11.008
- ISSN
- 0271-5317
- Abstract
- We aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) and microvascular complications in type 2 diabetes mellitus (T2DM) patients. It was hypothesized that lower 25(OH)D would be associated with increased microvascular complications in T2DM. A total of 257 T2DM patients (111 men, 146 women) who underwent diabetic microvascular complication (peripheral neuropathy, nephropathy, retinopathy) studies were recruited. Patients were categorized into 3 groups according to vitamin D status: vitamin D sufficient (n = 41, 25[OH]D >= 20 ng/mL), vitamin D insufficient (n = 132, 10 <= 25[OH]D < 20 ng/mL), and vitamin D deficient (n = 84, 25[OH]D < 10 ng/mL). In men, the prevalence of diabetic peripheral neuropathy (DPN) was significantly higher in patients with vitamin D deficiency than in those with insufficiency or sufficiency (38%, 11.7%, and 10%, respectively; P = .005). In addition, the prevalence of diabetic nephropathy (DN) was significantly higher in women with vitamin D deficiency than in the other 2 groups (40%, 20.6%, and 0%; P = .007). Compared with men in the vitamin D-sufficient group (reference), men in the vitamin D-deficient group had an increased risk of DPN after adjusting for confounding factors (odds ratio, 7.79; 95% confidence interval, 1.52-40.05). For women, when the vitamin D-sufficient group was used as a reference, those in the vitamin D-deficient group had an increased risk of DN after adjusting for confounding factors (odds ratio, 4.27; 95% confidence interval, 1.58-11.56). This present study found that a serum 25(OH)D level less than 10 ng/mL is independently associated with increased DPN in male patients and increased DN in female patients with T2DM. (C) 2016 Elsevier Inc. All rights reserved.
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