환경 바이오모니터링에서의 혈중 중금속 분석 숙련도 시험을 위한 표준물질 제조 및 적용성 평가
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임호섭 | - |
dc.contributor.author | 양민호 | - |
dc.contributor.author | 오세림 | - |
dc.contributor.author | 김소영 | - |
dc.contributor.author | 정호준 | - |
dc.contributor.author | 조용민 | - |
dc.contributor.author | 이정섭 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 이채관 | - |
dc.contributor.author | 문찬석 | - |
dc.contributor.author | 이종화 | - |
dc.date.accessioned | 2021-08-11T18:25:19Z | - |
dc.date.available | 2021-08-11T18:25:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1738-4087 | - |
dc.identifier.issn | 2233-8616 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9523 | - |
dc.description.abstract | Objectives: This study developed and validated reference materials (RMs) to analyze metal compounds in blood. Methods: We referred to KoNEHS (Korea National Environmental Health Survey) to estimate concentrations of blood metals (cadmium, Cd; lead, Pb; mercury, Hg) and applied analytical methods (inductively coupled plasma – mass spectroscopy, ICP-MS, for Cd and Pb; graphite furnace – atomic absorption spectrometry, GFAAS, for Cd and Pb; and direct mercury analyzer, DMA, for Hg). Homogeneity and stability tests were carried out. In addition, certified values and uncertainties of RMs were calculated through internal and external experiments. All RMs were developed and assessed in various forms according to element, analytical method, and two types of concentration levels high concentration for occupational exposure and low concentration for environmental exposure. Results: All samples showed acceptable homogeneity, except for low concentration of Cd in the GF-AAS method. Short- and long-term stabilities were satisfied by ANOVA testing. In the inter-laboratory comparison, robust medians were lower than the certified values of all RMs (robust median/reference value; 1.301/1.327 µg/L for Cd, ICP-MS, low concentration; 3.152/3.388 µg/L for Cd, ICP-MS, high concentration; 1.219/1.301 µg/L for Cd, GF-AAS, low concentration; 3.074/3.321 µg/L for Cd, GF-AAS, high concentration; 14.473/14.516 µg/L for Pb, ICP-MS, low concentration; 50.069/50.114 µg/L for Pb, ICP-MS, high concentration; 12.881/14.147 µg/L for Pb, GF-AAS, low concentration; 47.015/47.591 µg/L for Pb, GF-AAS, high concentration; 4.059/4.218 µg/L for Hg, DMA, low concentration; 11.474/11.181 µg/L for Hg, DMA, high concentration). Conclusion: This study demonstrates procedures for developing and validating RMs for biomonitoring in the field of the environmental health. | - |
dc.format.extent | 15 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국환경보건학회 | - |
dc.title | 환경 바이오모니터링에서의 혈중 중금속 분석 숙련도 시험을 위한 표준물질 제조 및 적용성 평가 | - |
dc.title.alternative | Development and Validation of Reference Material for Proficiency Testing of Blood Heavy Metals in Environmental Biomonitoring | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 한국환경보건학회지, v.42, no.6, pp 450 - 464 | - |
dc.citation.title | 한국환경보건학회지 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 450 | - |
dc.citation.endPage | 464 | - |
dc.identifier.kciid | ART002182711 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Biomonitoring | - |
dc.subject.keywordAuthor | blood cadmium | - |
dc.subject.keywordAuthor | blood lead | - |
dc.subject.keywordAuthor | blood mercury | - |
dc.subject.keywordAuthor | reference materials | - |
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