운동유발성 고혈압 주자의 울트라 마라톤 달리기가전구염증과 항염증 사이토카인 및 혈관내피세포기능인자에 미치는 영향Effects of Ultra-Marathon Running on Pro-inflammatory, Anti-inflammatory and Endothelial Function Factors in Athletes with Exercise-induced Hypertension
- Other Titles
- Effects of Ultra-Marathon Running on Pro-inflammatory, Anti-inflammatory and Endothelial Function Factors in Athletes with Exercise-induced Hypertension
- Authors
- 김철현; 강덕호; 김영주
- Issue Date
- 2016
- Publisher
- 대한스포츠의학회
- Keywords
- 심혈관질환; 사이토카인; 내피세포기능조절인자; 일산화질소; Cardiovascular disease; Cytokines; Exercise-induced hypertension; Nitric oxide
- Citation
- 대한스포츠의학회지, v.34, no.2, pp.169 - 175
- Journal Title
- 대한스포츠의학회지
- Volume
- 34
- Number
- 2
- Start Page
- 169
- End Page
- 175
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9539
- DOI
- 10.5763/kjsm.2016.34.2.169
- ISSN
- 1226-3729
- Abstract
- Running for a long distance in runners with exercise-induced hypertension (EIH) increases high blood pressure (BP) which causes myocardial burden, inducing elevation of cardiac markers. It is assumed to be associated with endothelial dysfunction, but has not been studied so far. The purpose of this study is to exam the responses of anti-inflammatory, inflammatory, and endothelial regulation factors to 100 km ultra-marathon of athletes who have EIH. For this study, we obtain and analysis interleukin-6, tumor necrosis factor-α, interleukin-10 (IL-10), monocyte chemoattractant protein-1, creatine kinase and nitric oxide (NO) from 100 km ultra-marathoners before and right after the 100 km race. There were 40 volunteers who had ever won the 100 km marathon race before more than one time. They had the graded exercise test with measurement of BP for assessing EIH. Among them, eight athletes were categorized to normal control group (NCG) and 10 athletes were assessed by EIH group (EIHG). The graded exercise test with treadmill was performed for the maximal strenuous exercise and BP. EIH was diagnosed as <140/90 mm Hg in normal and ≥210 mm Hg in maximal exercise. Marathoners including EIHG (n=10) and NCG (n=8) participated in the race and blood extracted from them before the race and right after the race. As results, EIHG had lower IL-10 than NCG during resting states and after the 100 km race EIHG had significantly lower NO concentration than NCG. Therefore, the NO in the endothelial is inhibited during strenuous endurance exercise, resulting in vasoconstriction with increasing the BP.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Sports Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.