Impact of the Occurrence While Sleeping of First Unprovoked Seizure on Seizure Recurrence: A Systematic Reviewopen access
- Authors
- Yang, T.-W.; Kim, Y.-S.; Kim, D.-H.; Ha, H.; Kwon, O.-Y.
- Issue Date
- Nov-2022
- Publisher
- Korean Neurological Association
- Keywords
- epilepsy; meta-analysis; prevalence; recurrence; seizures
- Citation
- Journal of Clinical Neurology (Korea), v.18, no.6, pp 642 - 652
- Pages
- 11
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Clinical Neurology (Korea)
- Volume
- 18
- Number
- 6
- Start Page
- 642
- End Page
- 652
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/101214
- DOI
- 10.3988/jcn.2022.18.6.642
- ISSN
- 1738-6586
2005-5013
- Abstract
- Background and Purpose The impact of the occurrence while sleeping of first unprovoked seizure (FUS) on seizure recurrence in people with FUS is currently unclear. This un-certainty makes it challenging for physicians to determine whether to apply antiseizure medications (ASMs) to people with FUS while sleeping (FUS-S). This study aimed to determine the impact of the occurrence while sleeping of FUS. Methods We searched the MEDLINE, Embase, Cochrane Library, Web of Science, and Sco-pus electronic databases. Among retrieved studies, we selected those that provided information on the number of people with FUS, and relapsed people among these in each instance of FUS-S and FUS when waking (FUS-W). We used a random-effects model for meta-analyses. Results Of the 3,582 identified studies, 13 were eligible for systematic review. Seven of these 13 studies were deemed adequate for inclusion in a meta-analysis since they provided infor-mation at the time point of 2 years follow-up after FUS. The seven studies were of high quality regarding their risk of bias. When combining these 7 studies, the total sample comprised 1,659 people, of which 626 had FUS-S and 1,033 had FUS-W. The relative risk of seizure recurrence between FUS-S and FUS-W was 1.627. The seizure recurrence rates (SRRs) were 59.8% and 36.5% in the FUS-S and FUS-W groups, respectively. Conclusions We verified that the SRR was higher among people with FUS-S than FUS-W. After 2 years of follow-up, the SRR in people with FUS-S was about 60%. It is preferable to initiate an ASM for people with FUS-S. Systematic review registration PROSPERO registration number CRD42021266191. © 2022 Korean Neurological Association.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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