Gait and axial postural abnormalities correlations in Parkinson's disease: A multicenter quantitative study
- Authors
- Pongmala, C.[Pongmala, C.]; Fabbri, M.[Fabbri, M.]; Zibetti, M.[Zibetti, M.]; Pitakpatapee, Y.[Pitakpatapee, Y.]; Wangthumrong, T.[Wangthumrong, T.]; Sangpeamsook, T.[Sangpeamsook, T.]; Srikajon, J.[Srikajon, J.]; Srivanitchapoom, P.[Srivanitchapoom, P.]; Youn, J.[Youn, J.]; Cho, J.W.[Cho, J.W.]; Kim, M.[Kim, M.]; Zamil, Shinawi H.M.[Zamil, Shinawi H.M.]; Obaid, M.T.[Obaid, M.T.]; Baumann, A.[Baumann, A.]; Margraf, N.G.[Margraf, N.G.]; Pona-Ferreira, F.[Pona-Ferreira, F.]; Leitão, M.[Leitão, M.]; Lobo, T.[Lobo, T.]; Ferreira, J.J.[Ferreira, J.J.]; Lopiano, L.[Lopiano, L.]; Artusi, C.A.[Artusi, C.A.]
- Issue Date
- Dec-2022
- Publisher
- Elsevier Ltd
- Keywords
- Axial posture; Gait; Parkinson' s disease; Postural abnormalities
- Citation
- Parkinsonism and Related Disorders, v.105, pp.19 - 23
- Indexed
- SCIE
SCOPUS
- Journal Title
- Parkinsonism and Related Disorders
- Volume
- 105
- Start Page
- 19
- End Page
- 23
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/101262
- DOI
- 10.1016/j.parkreldis.2022.10.026
- ISSN
- 1353-8020
- Abstract
- Introduction: Gait and axial postural abnormalities (PA) are common and disabling symptoms of Parkinson's disease (PD). The interplay between them has been poorly explored. Methods: A standardized protocol encompassing videos and photos for posture and gait analysis of PD patients with a clinically defined PA (MDS-UPDRS-III item 3.13 > 0) was used in 6 movement disorder centers. A comprehensive evaluation was performed to clarify the association between gait performance and the presence and severity of PA. Results: 225 PD patients were enrolled: 57 had severe PA, 149 mild PA, and 19 did not meet criteria for PA, according to a recent consensus agreement on PA definition. PD patients with severe PA were significantly older (p:0.001), with longer disease duration (p:0.007), worse MDS-UPDRS-II and –III scores and axial sub-scores (p < 0.0005), higher LEDD (p:0.002) and HY stage (p < 0.0005), and a significantly lower velocity (p < 0.001) and cadence (p:0.021), if compared to mild PA patients. The multiple regression analysis evaluating gait parameters and degrees of trunk/neck flexion showed that higher degrees of lumbar anterior trunk flexion were correlated with lower step length (OR -0.244; p:0.014) and lower velocity (OR -0.005; p:0.028). Conclusions: Our results highlight the possible impact of severe anterior trunk flection on PD patients’ gait, with a specific detrimental effect on gait velocity and step length. Personalized rehabilitation strategies should be elaborated based on the different features of PA, aiming to target a combined treatment of postural and specifically related gait pattern alterations. © 2022 Elsevier Ltd
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