Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activitiesopen access
- Authors
- Lee, BS[Lee, Bum Soo]; Ryoo, R[Ryoo, Rhim]; Park, JS[Park, Jin Song]; Choi, SU[Choi, Sang Un]; Jeong, SY[Jeong, Se Yun]; Ko, YJ[Ko, Yoon-Joo]; Kim, JK[Kim, Jung Kyu]; Kim, JC[Kim, Jin-Chul]; Kim, KH[Kim, Ki Hyun]
- Issue Date
- Oct-2022
- Publisher
- AMER CHEMICAL SOC
- Citation
- ACS OMEGA, v.7, no.43, pp.39456 - 39462
- Indexed
- SCOPUS
- Journal Title
- ACS OMEGA
- Volume
- 7
- Number
- 43
- Start Page
- 39456
- End Page
- 39462
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/101946
- DOI
- 10.1021/acsomega.2c06155
- ISSN
- 2470-1343
- Abstract
- Three isoindolinone alkaloids (1-3), including one new isoindolinone-type alkaloid, meyeroguilline E (1), and six other known compounds (4-9) were isolated from the poisonous mushroom Chlorophyllum molybdites (Agaricaceae). The structure of the new compound was determined using extensive spectroscopic analyses via one-dimensional (1D) and two-dimensional (2D) NMR data interpretation and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). To the best of our knowledge, compound 1 is the first example of a natural isoindolinone with a butanoic acid moiety, and this study is the first to detect the other known compounds (2-9) in C. molybdites. The isolated compounds (1-9) were examined for their multidrug resistance (MDR) reversal activity against MES-SA, MES-SA/DX5, HCT15, and HCT15/CL02 human cancer cells. Based on the results, 20 mu M of compounds 3 and 6 slightly potentiated paclitaxel (TAX)-induced cytotoxicity in MES-SA/ DX5, HCT15, and HCT15/CL02 cells; however, the compounds had no effect on the cytotoxicity against MES-SA and nonMDR cells.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
- Engineering > Chemical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.