N-Cyano sulfilimine functional group as a nonclassical amide bond bioisostere in the design of a potent analogue to anthranilic diamide insecticideopen access
- Authors
- Kang, OY[Kang, On-Yu]; Kim, E[Kim, Eunsil]; Lee, WH[Lee, Won Hyung]; Ryu, D[Ryu, Do Hyun]; Lim, HJ[Lim, Hwan Jung]; Park, SJ[Park, Seong Jun]
- Issue Date
- 6-Jan-2023
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v.13, no.3, pp.2004 - 2009
- Indexed
- SCIE
SCOPUS
- Journal Title
- RSC ADVANCES
- Volume
- 13
- Number
- 3
- Start Page
- 2004
- End Page
- 2009
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/102549
- DOI
- 10.1039/d2ra06988a
- ISSN
- 2046-2069
- Abstract
- To explore the potential of the N-cyano sulfilimine group as an amide bond isostere, a derivative of the blockbuster anthranilic diamide, chlorantramiliprole, was synthesized and evaluated with regard to its physicochemical properties, permeability, and biological activity. Given the combination of N-cyano sulfilimine chlorantraniliprole 1 and its strong hydrogen bond acceptor character, high permeability, and excellent insecticidal activity, the N-cyano sulfilimine functional group could be considered as an amide bond isostere.
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Collections - Graduate School > Chemistry > 1. Journal Articles
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