Augmented humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 after breakthrough infection in kidney transplant recipients who received 3 doses of coronavirus disease 2019 vaccineopen access
- Authors
- Yang, J[Yang, Jinyoung]; Lee, KW[Lee, Kyo Won]; Baek, JY[Baek, Jin Yang]; Bae, S[Bae, Seongman]; Lee, YH[Lee, Young Ho]; Kim, H[Kim, Haein]; Huh, K[Huh, Kyungmin]; Cho, SY[Cho, Sun Young]; Kang, CI[Kang, Cheol-In]; Chung, DR[Chung, Doo Ryeon]; Peck, KR[Peck, Kyong Ran]; Park, JB[Park, Jae Berm]; Kim, SH[Kim, Sung -Han]; Kim, TJ[Kim, Tae -Jong]; Kim, DM[Kim, Dong-Min]; Ko, JH[Ko, Jae-Hoon]
- Issue Date
- 1-Apr-2023
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- breakthrough infection (BI); cellular immunity; humoral immunity; kidney transplant; severe acute respiratory syndrome coronavirus; 2 (SARS-CoV-2)
- Citation
- AMERICAN JOURNAL OF TRANSPLANTATION, v.23, no.4, pp.565 - 572
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF TRANSPLANTATION
- Volume
- 23
- Number
- 4
- Start Page
- 565
- End Page
- 572
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/102834
- DOI
- 10.1016/j.ajt.2022.12.022
- ISSN
- 1600-6135
- Abstract
- Diminished immune response to coronavirus disease 2019 (COVID-19) vaccines and breakthrough infection (BI) is a major concern for solid organ transplant recipients. Humoral and cellular immune responses of kidney transplant (KT) recipients after a third COVID-19 vaccination were investigated compared to matched health care workers. Anti-severe acute respiratory syndrome coronavirus 2 spike protein antibody and severe acute respi-ratory syndrome coronavirus 2 specific interferon-gamma releasing assay (IGRA) were assessed. A total of 38 KT recipients, including 20 BI and 18 noninfection, were evaluated. In the KT BI group, antibody titers were significantly increased (median 5 to 724, binding antibody units/mL (P = 0.002) after the third vaccination, but IGRA responses were negligible. After BI, antibody titers increased (median 11 355 binding antibody unit/mL; P < 0.001) and there was a significant increase of IGRA responses to spike proteins (Spike1-Nil, median 0.05 to 0.41 IU/mL; P = 0.009). Antibody titers and IGRA responses were significantly higher in the BI than in the non -infection group after 6 months. Immune responses were stronger in the health care worker than in the KT cohort, but the gap became narrower after BI. In conclusion, KT recipients who experienced BI after 3 COVID-19 vac-cinations acquired augmented humoral and cellular immune responses.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/102834)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.