Persistence or regression of prediabetes and coronary artery calcification among adults without diabetesopen access
- Authors
- Cho, Y.[Cho, Y.]; Chang, Y.[Chang, Y.]; Ryu, S.[Ryu, S.]; Kim, Y.[Kim, Y.]; Jung, H.-S.[Jung, H.-S.]; Kang, J.[Kang, J.]; Choi, I.Y.[Choi, I.Y.]; Kim, C.-W.[Kim, C.-W.]; Oh, H.[Oh, H.]; Wild, S.H.[Wild, S.H.]; Byrne, C.D.[Byrne, C.D.]
- Issue Date
- 10-Jan-2023
- Publisher
- NLM (Medline)
- Keywords
- cardiovascular disease; cohort study; coronary artery calcification; prediabetes
- Citation
- European journal of endocrinology, v.188, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- European journal of endocrinology
- Volume
- 188
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/103583
- DOI
- 10.1093/ejendo/lvac001
- ISSN
- 0804-4643
- Abstract
- OBJECTIVE: The effect of changes in glycemic status on subclinical atherosclerosis is uncertain. We assessed the association of persistence, regression, or progression of prediabetes with coronary artery calcium score (CACS) as a measure of subclinical atherosclerosis. DESIGN: A cross-sectional study, comprising 126 765 adults, and longitudinal sub-study, comprising 40 622 adults (with baseline and at least 1 follow-up computed tomography scan to assess changes in CACS), were undertaken. METHODS: Changes in glycemic status over 1.5 years (interquartile range, 1.0-2.0) before the first CACS assessment were categorized according to 6 groups: persistent normoglycemia (reference), normoglycemia to prediabetes, normoglycemia to diabetes, prediabetes to normoglycemia, persistent prediabetes, and prediabetes to diabetes. Logistic regression was used to calculate the odds ratios (ORs) and 95% CIs for prevalent coronary artery calcification (CAC). Mixed models with random intercepts and random slopes were used to estimate 5-year CAC progression rates. RESULTS: Mean (SD) age was 41.3 (7.0) years (74.7% male) (n = 126 765). Multivariable-adjusted OR for prevalent CAC was 1.13 (95% CI, 1.08-1.18) for persistent prediabetes, 1.05 (0.98-1.12) for regression to normoglycemia, and 1.46 (95% CI, 1.27-1.67) for progression from prediabetes to diabetes, compared with persistent normoglycemia. Coronary artery calcification progression increased significantly in all prediabetes groups. Multivariable-adjusted ratio of 5-year CAC progression rates was 1.19 (95% CI, 1.16-1.22) (persistent prediabetes), 1.11 (1.07-1.14) (regression to normoglycemia), and 1.63 (95% CI, 1.26-2.10) (progression from prediabetes to diabetes). CONCLUSIONS: Unfavorable changes in glycemic status, including persistence of prediabetes or progression to diabetes from prediabetes, were associated with increased risk of CAC. © The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology.
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