The chronological changes in the seroprevalence of anti-hepatitis A virus IgG from 2005 to 2019: Experience at four centers in the capital area of South Koreaopen access
- Authors
- Lim, DH[Lim, Dae Hyun]; Sohn, W[Sohn, Won]; Jeong, JY[Jeong, Jae Yoon]; Oh, H[Oh, Hyunwoo]; Lee, JG[Lee, Jae Gon]; Yoon, EL[Yoon, Eileen. L. L.]; Kim, TY[Kim, Tae Yeob]; Nam, S[Nam, Seungwoo]; Sohn, JH[Sohn, Joo Hyun]
- Issue Date
- 2-Dec-2022
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- hepatitis A virus; seroprevalence; vaccination
- Citation
- MEDICINE, v.101, no.48, pp.E31639
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDICINE
- Volume
- 101
- Number
- 48
- Start Page
- E31639
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/104809
- DOI
- 10.1097/MD.0000000000031639
- ISSN
- 0025-7974
- Abstract
- Although universal vaccination has been administered to toddlers, South Korea has had periodic nationwide outbreaks of acute hepatitis A since the late 2000s. We examined the chronological changes in the seroprevalence of anti-hepatitis A virus (HAV) immunoglobulin G (IgG) over the past 15 years (2005-2019). We retrospectively collected data from 45,632 subjects who underwent anti-HAV IgG testing without evidence of acute HAV infection at four centers in the capital area of South Korea between January 2005 and December 2019. The seroprevalence of anti-HAV IgG was analyzed according to age and compared among seven age groups and five time periods. Additionally, age-period-cohort analyses were used to identify the age, period, and cohort effects of the seroprevalence of anti-HAV IgG. The mean age of the enrolled subjects was 39.2 +/- 19.2 years, and the average anti-HAV IgG positivity rate was 66.4%. During the 15 years, the seroprevalence of anti-HAV IgG in people aged 0 to 19 years significantly increased over time (P .001). In people aged 20 to 29 years, the seroprevalence slightly decreased to that of the early 2010s (31.3% in 2005-2007 to 19.7% in 2011-2013) but rebounded to 39.5% in 2017 to 2019. In contrast, the seroprevalence of anti-HAV IgG in those aged 30 to 49 years decreased over time (P .001). The seroprevalence of anti-HAV IgG in those aged 20 to 39 years in 2017 to 2019 was still less than 40%. In addition, the seroprevalence of anti-HAV IgG in people aged 50 to 59 years has recently decreased. Since the introduction of the universal vaccination, the seroprevalence of anti-HAV IgG in children and young adults has gradually increased. However, the seroprevalence of anti-HAV IgG in people in their 20s remains low, and the seroprevalence of anti-HAV IgG in people in their 30s and 40s is gradually decreasing. Therefore, a new strategy for HAV vaccination is needed for those in their 20s to 40s.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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