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Rh(III)-Catalyzed C8-Spiroannulation of 1-Aminonaphthalenes with Maleimides
- Authors
- Chung, EJ[Chung, Eunjae]; Kim, S[Kim, Suho]; Rakshit, A[Rakshit, Amitava]; Singh, P[Singh, Pargat]; Park, J[Park, Jaewook]; Jeong, T[Jeong, Taejoo]; Kim, IS[Kim, In Su]
- Issue Date
- 18-Jul-2023
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v.88, no.15, pp.11227 - 11239
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 88
- Number
- 15
- Start Page
- 11227
- End Page
- 11239
- ISSN
- 0022-3263
- Abstract
- The rhodium(III)-catalyzed C8-spiroannulation of 1-aminonaphthaleneswith maleimides is described herein. Initially formed C8-alkenylated1-aminonaphthalenes can intercept nucleophilic 1-amino groups throughthe intramolecular aza-Michael reaction, resulting in the formationof spirofused tetracyclic frameworks. This protocol displayed a widesubstrate scope and a broad functional group compatibility. The syntheticutility of this process is demonstrated by the gram-scale synthesis,late-stage modification, and synthetic transformations.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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