Ophthalmologic Manifestations of Ocular Myasthenia Gravis; [안중증근무력증의 안과적 임상 양상]open access
- Authors
- Seo, Yong Hoon; Yang, Won Jin; Oh, Shin Yeop
- Issue Date
- Oct-2023
- Publisher
- Korean Ophthalmological Society (KOS)
- Keywords
- Cholinesterase inhibitor; Diplopia; Ocular myasthenia gravis; Ptosis; Strabismus
- Citation
- Journal of Korean Ophthalmological Society, v.64, no.10, pp 957 - 965
- Pages
- 9
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Journal of Korean Ophthalmological Society
- Volume
- 64
- Number
- 10
- Start Page
- 957
- End Page
- 965
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/109411
- DOI
- 10.3341/jkos.2023.64.10.957
- ISSN
- 0378-6471
2092-9374
- Abstract
- Purpose: We investigated the ophthalmic manifestations observed in patients diagnosed with ocular myasthenia gravis. Methods: In total, 58 patients diagnosed with ocular myasthenia gravis visited the ophthalmology and neurology departments between January 2011 and August 2022. Patients were followed for > 6 months; their ophthalmic manifestations were analyzed retrospectively. Results: The study included 29 males and 29 females with a mean age of 55.52 ± 15.60 years. Among the patients, 31 tested positive for anti-acetylcholine receptor antibodies, resulting in a positive rate of 53.45%. Abnormalities in repeated nerve stimulation tests were observed in 33.33% of the patients. The antibody-positive group exhibited a higher frequency of progression to generalized myasthenia gravis (p = 0.011) and a higher incidence of chest abnormalities (p < 0.001) compared to the antibody-negative group. Horizontal and vertical diplopia were commonly observed in a complex group of patients with diplopia and blepharoptosis (p < 0.001); there was a difference in the pattern of strabismus between the diplopia single group with esotropia and the complex group with exotropia (p = 0.029). In addition, the combination group demonstrated a higher antibody titer (p = 0.034), a higher frequency of abnormalities in repeated nerve stimulation tests (p = 0.022), and a higher incidence of chest abnormalities (p = 0.022). Conclusions: The anti-acetylcholine receptor antibody-positive group had a higher incidence of progression to generalized myasthenia gravis; moreover, the complex group of patients with diplopia and ptosis exhibited elevated levels of anti-acetylcholine receptor antibodies and frequently accompanied both horizontal and vertical strabismus. © 2023 The Korean Ophthalmological Society.
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