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Cited 13 time in webofscience Cited 12 time in scopus
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Prognostic Significance for Long-Term Outcomes Following Radical Prostatectomy in Men with Prostate Cancer: Evaluation with Prostate Imaging Reporting and Data System Version 2open access

Authors
Kim, R.[Kim, R.]Kim, C.K.[Kim, C.K.]Park, J.J.[Park, J.J.]Kim, J.H.[Kim, J.H.]Seo, S.I.[Seo, S.I.]Jeon, S.S.[Jeon, S.S.]Lee, H.M.[Lee, H.M.]
Issue Date
Feb-2019
Publisher
KOREAN RADIOLOGICAL SOC
Keywords
Outcome; PI-RADS; Prognosis; Prostate cancer; Prostatectomy
Citation
KOREAN JOURNAL OF RADIOLOGY, v.20, no.2, pp.256 - 264
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF RADIOLOGY
Volume
20
Number
2
Start Page
256
End Page
264
URI
https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/10996
DOI
10.3348/kjr.2018.0613
ISSN
1229-6929
Abstract
Objective: To retrospectively determine whether the use of the Prostate Imaging Reporting and Data System (PI-RADS) version 2 (v2) helps predict long-term outcomes for prostate cancer (PCa) patients following radical prostatectomy (RP). Materials and Methods: A total of 166 patients with localized PCa evaluated with multiparametric magnetic resonance imaging (mpMRI) at 3T before RP were enrolled. Three groups were created based on PI-RADS v2 score used to predict clinical outcomes: group A, >= 3; group B, >= 4; group C, 5. We calculated biochemical recurrence-free survival (RFS) and progression-free survival (PFS). Cox proportion hazards models were used to identify variables predictive of biochemical recurrence and disease progression. Results: During a median follow-up of 9.1 years, biochemical recurrence occurred in 67 patients (40.4%) and disease progression occurred in 55 patients (33.1%). In all groups, 10-year RFS and 10-year PFS were significantly lower for PI-RADS scores >= 3, >= 4 and 5 than for score < 3, < 4 and < 5 (p < 0.05), respectively. In multivariate analysis, PI-RADS score >= 3 and score 5 were significant independent risk marker for biochemical recurrence (hazard ratio [HR] = 5.58, p = 0.018; HR = 1.75, p = 0.033) and disease progression (HR = 3.99, p = 0.047; HR = 2.31, p = 0.040). Moderate inter-observer agreement was seen for PI-RADS scoring. Conclusion: PI-RADS v2 may be used to predict long-term outcomes following RP in PCa.
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