A signal amplifying photoelectrochemical immunosensor based on the synergism of Au@CoFe2O4 and CdS/NiCo2O4 for the sensitive detection of neuron-specific enolases
- Authors
- Song, Na; Chen, Jingui; Ren, Xiang; Wu, Dan; Ma, Hongmin; Li, Faying; Ju, Huangxian; Wei, Qin
- Issue Date
- 15-Jun-2024
- Publisher
- Elsevier B.V.
- Keywords
- Au@CoFe<sub>2</sub>O<sub>4</sub>; Bandgap-matched; CdS/NiCo<sub>2</sub>O<sub>4</sub>; NSE; Photoelectrochemistry
- Citation
- Sensors and Actuators B: Chemical, v.409
- Indexed
- SCIE
SCOPUS
- Journal Title
- Sensors and Actuators B: Chemical
- Volume
- 409
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/110128
- DOI
- 10.1016/j.snb.2024.135593
- ISSN
- 0925-4005
0925-4005
- Abstract
- Neuron-specific enolase (NSE), a marker of small cell lung cancer, is over-expressed in patient serum. To reduce the threat of lung cancer to human health and life, a rapid and effective method for the sensitive detection of NSE is necessary. In this study, a sandwich-type photoelectrochemical (PEC) immunosensor for the rapid and sensitive detection of NSE was constructed. To provide a powerful and stable photocurrent signal, the bandgap-matched CdS/NiCo2O4 was used as the substrate material. In addition, Au@CoFe2O4, which can form a step electron transfer mode with NiCo2O4, was proposed for the first time as a second antibody (Ab2) marker to amplify photoelectric signals. The constructed signal-amplified PEC immunosensor showed good linearity in the range of 1 pg/mL − 100 ng/mL with a detection limit as low as 0.24 pg/mL (S/N=3). The constructed PEC immunosensor has shown excellent stability, selectivity, reproducibility, and repeatability. It showed recoveries in the range of 98% − 105% and relative standard deviations (RSD) within 5% in sample analysis. The method proposed in this study is expected to be more widely used in the future for the detection of other disease markers as well as environmental pollutants. © 2024 Elsevier B.V.
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Collections - Graduate School > Chemistry > 1. Journal Articles
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