Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates
- Authors
- Seong, Duhwan; Choi, Yeonsun; Choi, In Cheul; Lee, Jaebeom; Choi, Jae Hyuk; Park, Ji Hun; Nam, Jae Jun; Ju, Jaewon; Ryoo, Hyun Jae; Kwak, Donghee; Lee, Joonyeol; Kim, Seong-Gi; Kim, Dong Hwee; Park, Jong Woong; Shin, Mikyung; Son, Donghee
- Issue Date
- 2-Feb-2024
- Publisher
- John Wiley and Sons Inc
- Keywords
- adhesive; nerve repair; neurorrhaphy; self-healing; stretchable
- Citation
- Advanced Materials, v.36, no.16
- Indexed
- SCIE
SCOPUS
- Journal Title
- Advanced Materials
- Volume
- 36
- Number
- 16
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/110463
- DOI
- 10.1002/adma.202307810
- ISSN
- 0935-9648
1521-4095
- Abstract
- The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair. © 2024 Wiley-VCH GmbH.
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Collections - SKKU Institute for Convergence > Biomedical Engineering > 1. Journal Articles
- Information and Communication Engineering > School of Electronic and Electrical Engineering > 1. Journal Articles
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