Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers
- Authors
- Park, E.[Park, E.]; Choi, Y.-L.[Choi, Y.-L.]; Ahn, M.-J.[Ahn, M.-J.]; Han, J.[Han, J.]
- Issue Date
- Jul-2019
- Publisher
- Elsevier GmbH
- Keywords
- FISH; Histology; Immunohistochemistry; Lung adenocarcinoma; Non-small cell lung cancer (NSCLC); ROS1
- Citation
- Pathology Research and Practice, v.215, no.7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Pathology Research and Practice
- Volume
- 215
- Number
- 7
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/11791
- DOI
- 10.1016/j.prp.2019.152441
- ISSN
- 0344-0338
- Abstract
- Background: ROS1 rearrangement accounts for 1%–2% of non-small cell lung cancer (NSCLC) with a remarkable response to crizotinib. Although ROS1-rearranged tumors are known to have characteristic histologic features, only a few studies have investigated the histologic features of advanced-stage ROS1-rearranged tumors. Methods: We analyzed the histopathologic features of ROS1-rearranged tumors in advanced-stage NSCLC patients and assessed the ROS1 immunohistochemistry (IHC) staining patterns of ROS1-rearranged cases. Results: A total of 37 ROS1 fluorescence in situ hybridization (FISH)-positive cases and 64 ROS1 FISH-negative cases were analyzed, and all tumors were EGFR-, ALK-, and RET-negative. Solid pattern, round nuclei with macronucleoli, solid signet-ring cells, extracellular mucin, and a close relation with adjacent bronchioles were significantly associated with ROS1 rearrangement, and the solid signet-ring cell feature was exclusively identified in ROS1-rearranged tumors. ROS1 IHC showed a 97.3% sensitivity when weak to strong protein expression was considered positive. Conclusions: Our findings highlight distinct histologic features of ROS1-rearranged tumors, including their nuclear features. A thorough understanding of ROS1 rearrangement-related histologic features would be helpful to identify ROS1-rearranged tumors in advanced-stage NSCLC. © 2019 Elsevier GmbH
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