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Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities
- Authors
- Kim D.H.[Kim D.H.]; Kim C.S.[Kim C.S.]; Subedi L.[Subedi L.]; Kim S.Y.[Kim S.Y.]; Lee K.R.[Lee K.R.]
- Issue Date
- 10-Oct-2019
- Publisher
- Elsevier Ltd
- Keywords
- Anti-Inflammatory activities; Indole alkaloids; NIRAM; Polygonum tinctorium
- Citation
- Tetrahedron Letters, v.60, no.41
- Indexed
- SCIE
SCOPUS
- Journal Title
- Tetrahedron Letters
- Volume
- 60
- Number
- 41
- ISSN
- 0040-4039
- Abstract
- Phytochemical investigation of EtOH extract of NIRAM, natural dye from Polygonum tinctorium, resulted in the purification of nine alkaloid compounds (1–9) including four new compounds (1–4). Structures of these new compounds were elucidated by 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, 1H–13C HSQC, 1H–13C HMBC), IR, UV, HR-ESI-MS, and ECD spectra. Isolated compounds (1–9) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells. Compounds 1–3, 5, and 7 showed potent NO production inhibitory activities, with IC50 values of 3.88–22.87 μM. © 2019 Elsevier Ltd
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