Thiohydantoin and Hydantoin Derivatives from the Roots of Armoracia rusticana and Their Neurotrophic and Anti-neuroinflammatory Activities
- Authors
- Lee T.H.[Lee T.H.]; Khan Z.[Khan Z.]; Kim S.Y.[Kim S.Y.]; Lee K.R.[Lee K.R.]
- Issue Date
- Nov-2019
- Publisher
- American Chemical Society
- Citation
- Journal of Natural Products, v.82, no.11, pp.3020 - 3024
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Natural Products
- Volume
- 82
- Number
- 11
- Start Page
- 3020
- End Page
- 3024
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/13492
- DOI
- 10.1021/acs.jnatprod.9b00527
- ISSN
- 0163-3864
- Abstract
- Two new thiohydantoins (1 and 3) and three new hydantoins (2, 4, and 5) along with three known compounds (6-8) were isolated from roots of horseradish. Physical data analysis including NMR (1H and 13C NMR, 1H-1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for structure elucidation of the new compounds 1-5. Potential neuroprotective effects of all compounds (1-8) on nerve growth factor (NGF) induction in C6 glioma were also evaluated. Among these compounds, 1b and 2a exhibited potent NGF secretion stimulation activities (NGF secretion levels: 153.59 ± 5.44% and 141.99 ± 5.21%, respectively). Their anti-neuroinflammatory activities were also assessed based on their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-stimulated murine microglia. Compound 7 marginally inhibited NO production with an IC50 value of 32.6 μM. © 2019 American Chemical Society and American Society of Pharmacognosy.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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