Pantheric Acids A-C from a Poisonous Mushroom, Amanita pantherina, Promote Lipid Accumulation in Adipocytes
- Authors
- Lee, S.R.[Lee, S.R.]; Yi, S.A.[Yi, S.A.]; Nam, K.H.[Nam, K.H.]; Ryoo, R.[Ryoo, R.]; Lee, J.[Lee, J.]; Kim, K.H.[Kim, K.H.]
- Issue Date
- Dec-2019
- Publisher
- American Chemical Society
- Citation
- Journal of Natural Products, v.82, no.12, pp.3489 - 3493
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Natural Products
- Volume
- 82
- Number
- 12
- Start Page
- 3489
- End Page
- 3493
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/13683
- DOI
- 10.1021/acs.jnatprod.9b00782
- ISSN
- 0163-3864
- Abstract
- Amanita pantherina is a poisonous mushroom that causes muscle cramps, insanity, and audiovisual disorders. As part of our systematic study on Korean mushrooms, a chemical investigation of A. pantherina fruiting bodies resulted in the isolation and structural identification of three new fatty acid derivatives, pantheric acids A-C (1-3), and a known compound, 1,10-dimethyl ester-2-decenedioic acid (4). Although 1,10-dimethyl ester-2-decenedioic acid (4) was previously reported as a synthetic product, it was structurally identified from a natural source for the first time. The structures of the new compounds were established by detailed analysis of 1D and 2D (1H-1H COSY, HSQC, and HMBC) NMR, HRMS, and LC/MS/MS data. The absolute configurations of compounds 1 and 2 were unambiguously determined by a recently developed method using competing enantioselective acylation coupled with LC/MS analysis. The isolated compounds (1-4) were evaluated for their effects on lipid accumulation during adipocyte maturation. Pantheric acids A-C (1-3) promoted the enlargement of lipid droplets in 3T3-L1 adipocytes and altered lipid metabolism by inducing lipogenesis and inhibiting lipolysis. Our findings provide experimental evidence suggesting the potential adverse effects of pantheric acids A-C from a poisonous mushroom on lipid metabolism. © 2019 American Chemical Society and American Society of Pharmacognosy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.