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Emergence of an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A by capsular switching
- Authors
- Baek, JY[Baek, Jin Yang]; Kim, SH[Kim, So Hyun]; Kang, CI[Kang, Cheol-In]; Chung, DR[Chung, Doo Ryeon]; Peck, KR[Peck, Kyong Ran]; Song, JH[Song, Jae-Hoon]; Ko, KS[Ko, Kwan Soo]
- Issue Date
- Dec-2018
- Publisher
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
- Keywords
- Extensively drug-resistant; Pneumococci; Serotype 15A; Serotype 11A; ST8279; Capsular switching
- Citation
- INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, v.308, no.8, pp.986 - 989
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- Volume
- 308
- Number
- 8
- Start Page
- 986
- End Page
- 989
- ISSN
- 1438-4221
- Abstract
- Recently, we have identified an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A isolate from a patient with bacterial meningitis. It belonged to sequence type 8279 (ST8279), a clone identified as XDR serotype 11A isolated in South Korea. We obtained and compared the genome sequences of an XDR 15A and an XDR 11A isolate. The genomes of two XDR isolates were highly identical, except for the capsular polysaccharide (cps) locus and another small region. Capsular switching from 11A to 15A may have occurred via recombination of the cps locus. The emergence of a new XDR clone via capsular switching would be a great concern for public health and in clinical settings.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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