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Recent Advances in pH- or/and Photo-Responsive Nanovehicles
- Authors
- Shin, Y[Shin, Yuseon]; Husni, P[Husni, Patihul]; Kang, K[Kang, Kioh]; Lee, D[Lee, Dayoon]; Lee, S[Lee, Sehwa]; Lee, E[Lee, Eunseong]; Youn, Y[Youn, Yuseok]; Oh, K[Oh, Kyungtaek]
- Issue Date
- May-2021
- Publisher
- MDPI
- Keywords
- chemotherapy; nanovehicles; light; pH; stimuli; photothermal; photodynamic; protonation; acid-labile bond
- Citation
- PHARMACEUTICS, v.13, no.5
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACEUTICS
- Volume
- 13
- Number
- 5
- ISSN
- 1999-4923
- Abstract
- The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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