Fully implantable and bioresorbable cardiac pacemakers without leads or batteriesopen access
- Authors
- Choi, YS[Choi, Yeon Sik]; Yin, RT[Yin, Rose T.]; Pfenniger, A[Pfenniger, Anna]; Koo, J[Koo, Jahyun]; Avila, R[Avila, Raudel]; Lee, KB[Benjamin Lee, K.]; Chen, SW[Chen, Sheena W.]; Lee, G[Lee, Geumbee]; Li, G[Li, Gang]; Qiao, Y[Qiao, Yun]; Murillo-Berlioz, A[Murillo-Berlioz, Alejandro]; Kiss, A[Kiss, Alexi]; Han, SL[Han, Shuling]; Lee, SM[Lee, Seung Min]; Li, CH[Li, Chenhang]; Xie, ZQ[Xie, Zhaoqian]; Chen, YY[Chen, Yu-Yu]; Burrell, A[Burrell, Amy]; Geist, B[Geist, Beth]; Jeong, H[Jeong, Hyoyoung]; Kim, J[Kim, Joohee]; Yoon, HJ[Yoon, Hong-Joon]; Banks, A[Banks, Anthony]; Kang, SK[Kang, Seung-Kyun]; Zhang, ZJ[Zhang, Zheng Jenny]; Haney, CR[Haney, Chad R.]; Sahakian, AV[Sahakian, Alan Varteres]; Johnson, D[Johnson, David]; Efimova, T[Efimova, Tatiana]; Huang, YG[Huang, Yonggang]; Trachiotis, GD[Trachiotis, Gregory D.]; Knight, BP[Knight, Bradley P.]; Arora, RK[Arora, Rishi K.]; Efimov, IR[Efimov, Igor R.]; Rogers, JA[Rogers, John A.]
- Issue Date
- Oct-2021
- Publisher
- NATURE RESEARCH
- Citation
- NATURE BIOTECHNOLOGY, v.39, no.10, pp.1228 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE BIOTECHNOLOGY
- Volume
- 39
- Number
- 10
- Start Page
- 1228
- End Page
- +
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/17607
- DOI
- 10.1038/s41587-021-00948-x
- ISSN
- 1087-0156
- Abstract
- A biodegradable pacemaker without external leads improves the safety of temporary cardiac pacing. Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.
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