T-Cell-Derived Nanovesicles for Cancer Immunotherapy
- Authors
- Hong, J[Hong, Jihye]; Kang, M[Kang, Mikyung]; Jung, M[Jung, Mungyo]; Lee, YY[Lee, Yun Young]; Cho, Y[Cho, Yongbum]; Kim, C[Kim, Cheesue]; Song, SY[Song, Seuk Young]; Park, CG[Park, Chun Gwon]; Doh, J[Doh, Junsang]; Kim, BS[Kim, Byung-Soo]
- Issue Date
- Aug-2021
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cancer; cytotoxic T cells; exhaustion; immunotherapy; nanovesicles
- Citation
- ADVANCED MATERIALS, v.33, no.33
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED MATERIALS
- Volume
- 33
- Number
- 33
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/17608
- DOI
- 10.1002/adma.202101110
- ISSN
- 0935-9648
- Abstract
- Although T-cell therapy is a remarkable breakthrough in cancer immunotherapy, the therapeutic efficacy is limited for solid tumors. A major cause of the low efficacy is T-cell exhaustion by immunosuppressive mechanisms of solid tumors, which are mainly mediated by programmed death-ligand 1 (PD-L1) and transforming growth factor-beta (TGF-beta). Herein, T-cell-derived nanovesicles (TCNVs) produced by the serial extrusion of cytotoxic T cells through membranes with micro-/nanosized pores that inhibit T-cell exhaustion and exhibit antitumoral activity maintained in the immunosuppressive tumor microenvironment (TME) are presented. TCNVs, which have programmed cell death protein 1 and TGF-beta receptor on their surface, block PD-L1 on cancer cells and scavenge TGF-beta in the immunosuppressive TME, thereby preventing cytotoxic-T-cell exhaustion. In addition, TCNVs directly kill cancer cells via granzyme B delivery. TCNVs successfully suppress tumor growth in syngeneic-solid-tumor-bearing mice. Taken together, TCNV offers an effective cancer immunotherapy strategy to overcome the tumor's immunosuppressive mechanisms.
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Collections - SKKU Institute for Convergence > Biomedical Engineering > 1. Journal Articles
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