Retinal Vein Occlusion and the Risk of Dementia: A Nationwide Cohort Study
- Authors
- Nam, G.E.[Nam, G.E.]; Han, K.[Han, K.]; Park, S.H.[Park, S.H.]; Cho, K.H.[Cho, K.H.]; Song, S.J.[Song, S.J.]
- Issue Date
- Jan-2021
- Publisher
- Elsevier Inc.
- Citation
- American Journal of Ophthalmology, v.221, pp.181 - 189
- Indexed
- SCIE
SCOPUS
- Journal Title
- American Journal of Ophthalmology
- Volume
- 221
- Start Page
- 181
- End Page
- 189
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/1838
- DOI
- 10.1016/j.ajo.2020.07.050
- ISSN
- 0002-9394
- Abstract
- Purpose: Retinal vascular change is associated with changes in the brains of patients with dementia; however, there is limited evidence regarding the relationship between retinal vein occlusion (RVO) and risk of dementia. This study investigated the association between RVO and subsequent risk of dementia using a cohort consisting of the entire Korean population. Design: Retrospective cohort study. Methods: This study was based on the data from participants ≥40 years of age who underwent health examinations between 2009 and 2010 provided by the South Korean National Health Insurance Service. The RVO group (n = 46,259) consisted of patients whose initial diagnoses were between 2006 and 2010. The comparison group (3 per RVO patient; n = 138,777) was selected using propensity score matching according to age, sex, and systolic blood pressure. Multivariate Cox proportional hazard regression models were performed. Results: During a mean follow-up of 6.6 years, 14,727 cases of dementia developed. From the Kaplan-Meier curves, probabilities of cases for all types of dementia were significantly increased in the RVO group, relative to the comparison group (all log-rank P <.001). After all confounding variables were adjusted, the RVO group exhibited increased risks of subsequent all-cause dementia (hazard ratio [HR]: 1.16; 95% confidence interval [CI]: 1.12-1.21), Alzheimer's disease (HR: 1.15; 95% CI: 1.11-1.20), and vascular dementia (HR: 1.24; 95% CI: 1.12-1.37), relative to the comparison group. The presence of RVO was significantly associated with increased risks of all 3 types of dementia both in hypertensive and nonhypertensive individuals. Conclusions: In this large-scale population-based cohort study, RVO was significantly associated with increased risks of all-cause dementia, Alzheimer's disease, and vascular dementia. © 2020 Elsevier Inc.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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