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Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates
- Authors
- Kim, SY[Kim, Su-Young]; Jhun, BW[Jhun, Byung Woo]; Moon, SM[Moon, Seong Mi]; Shin, SH[Shin, Sun Hye]; Jeon, K[Jeon, Kyeongman]; Kwon, OJ[Kwon, O. Jung]; Yoo, IY[Yoo, In Young]; Huh, HJ[Huh, Hee Jae]; Ki, CS[Ki, Chang-Seok]; Lee, NY[Lee, Nam Yong]; Shin, SJ[Shin, Sung Jae]; Daley, CL[Daley, Charles L.]; Suh, GY[Suh, Gee Young]; Koh, WJ[Koh, Won-Jung]
- Issue Date
- Sep-2018
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- Mycobacterium avium complex; Mycobacterium abscessus complex; moxifloxacin; resistance; gyrase mutation
- Citation
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.62, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Volume
- 62
- Number
- 9
- ISSN
- 0066-4804
- Abstract
- Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
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