Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Koreaopen access
- Authors
- Song, Y.-J.[Song, Y.-J.]; Yang, J.-S.[Yang, J.-S.]; Yoon, H.J.[Yoon, H.J.]; Nam, H.-S.[Nam, H.-S.]; Lee, S.Y.[Lee, S.Y.]; Cheong, H.-K.[Cheong, H.-K.]; Park, W.-J.[Park, W.-J.]; Park, S.H.[Park, S.H.]; Choi, B.Y.[Choi, B.Y.]; Kim, S.S.[Kim, S.S.]; Ki, M.[Ki, M.]
- Issue Date
- 15-Apr-2018
- Publisher
- KOREAN SOC EPIDEMIOLOGY
- Keywords
- Asymptomatic infection; Epidemiology; Middle East Respiratory Syndrome coronavirus; Nosocomial infections; Outbreak; Enzyme-linked immunespecific assay
- Citation
- EPIDEMIOLOGY AND HEALTH, v.40
- Indexed
- SCOPUS
KCI
- Journal Title
- EPIDEMIOLOGY AND HEALTH
- Volume
- 40
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/20339
- DOI
- 10.4178/epih.e2018014
- ISSN
- 2092-7193
- Abstract
- OBJECTIVES: The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status. METHODS: Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results. RESULTS: The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis. CONCLUSIONS: The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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