Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/IINK/T-cell lymphoma
- Authors
- Kwong, YL[Kwong, Y. L.]; Kim, SJ[Kim, S. J.]; Tse, E[Tse, E.]; Oh, SY[Oh, S. Y.]; Kwak, JY[Kwak, J. Y.]; Eom, HS[Eom, H. S.]; Do, YR[Do, Y. R.]; Mun, YC[Mun, Y. C.]; Lee, SR[Lee, S. R.]; Shin, HJ[Shin, H. J.]; Suh, C[Suh, C.]; Chuang, SS[Chuang, S. S.]; Lee, YS[Lee, Y. S.]; Lim, ST[Lim, S. T.]; Izutsu, K[Izutsu, K.]; Suzuki, R[Suzuki, R.]; Relander, T[Relander, T.]; d'Amore, F[d'Amore, F.]; Schmitz, N[Schmitz, N.]; Jaccard, A[Jaccard, A.]; Kim, WS[Kim, W. S.]
- Issue Date
- Jan-2018
- Publisher
- OXFORD UNIV PRESS
- Keywords
- stage I/IINK/T-cell lymphomas; concurrent chemoradiotherapy; sequential chemotherapy and radiotherapy
- Citation
- ANNALS OF ONCOLOGY, v.29, no.1, pp.256 - 263
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 29
- Number
- 1
- Start Page
- 256
- End Page
- 263
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/21383
- DOI
- 10.1093/annonc/mdx684
- ISSN
- 0923-7534
- Abstract
- Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/IINK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT+RT; RT+CT) and concurrent modalities (CCRT; CCRT+CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated. Results: For CR, stage (P = 0.027), prognostic index for NK/T-cell lymphoma (PINK) (P = 0.026) and types of initial treatment (P = 0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P = 0.021) and PINK-EBV DNA (PINK-E) (P = 0.002) significantly impacted on PFS; whereas ECOG performance score (P = 0.008) and stage (P < 0.001) significantly impacted on OS. For comparing CCRT +/- CT and sequential CT+RT, CCRT +/- CT patients (n = 190) were similar to sequential CT+RT patients (n = 54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT +/- CT patients had CR rate, PFS and OS comparable with sequential CT+RT patients on multivariate and Cox regression analyses. Conclusions: In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CTthornRT gave similar outcome.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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