Increased Response Rates to Salvage Chemotherapy Administered after PD-1 /PD-L1 Inhibitors in Patients with Non-Small Cell Lung Cancer
- Authors
- Park, SE[Park, Song Ee]; Lee, SH[Lee, Se Hoon]; Ahn, JS[Ahn, Jin Seok]; Ahn, MJ[Ahn, Myung-Ju]; Park, K[Park, Keunchil]; Sun, JM[Sun, Jong-Mu]
- Issue Date
- Jan-2018
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Immunotherapy; Chemotherapy; Response; Non-small cell lung cancer; NSCLC
- Citation
- JOURNAL OF THORACIC ONCOLOGY, v.13, no.1, pp.106 - 111
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THORACIC ONCOLOGY
- Volume
- 13
- Number
- 1
- Start Page
- 106
- End Page
- 111
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/21404
- DOI
- 10.1016/j.jtho.2017.10.011
- ISSN
- 1556-0864
- Abstract
- Introduction: Although programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors have shown some efficacy in treating advanced NSCLC, their benefits are limited to only a subset of patients. Advanced NSCLC is generally treated with a chemotherapy and immunotherapy series. Here we evaluated whether PD-1/PD-L1 inhibitors affect the antitumor effects of salvage chemotherapy administered after immunotherapy (SCAI) in patients with NSCLC.& para;& para;Methods: This study included patients with available SCAI response data. We compared the SCAI objective response rates (ORRs) with the ORRs after the last chemotherapy administered before immunotherapy (LCBI).& para;& para;Results: In total, 73 patients met the inclusion criteria and were included in the analyses. Of these patients, 10 received PD-1/PD-L1 inhibitors as first-line therapy and the remaining 63 had available LCBI response data. Of the 73 patients treated with SCAI, 39 (53.4%) achieved the ORR, whereas the ORR of LCBI was 34.9% (22 of 63) (p = 0.03). We also compared the ORRs of the SCAI and LCBI groups after stratification into platinum doublet therapy versus nonplatinum monotherapy. The ORRs for platinum doublet SCAI and LCBI therapies were 66.7% (16 of 24) and 39.5% (17 of 43), respectively (p = 0.03), whereas for nonplatinum SCAI and LCBI monotherapies they were 46.9% (23 of 49) and 25.0% (5 of 20), respectively (p = 0.09).& para;& para;Conclusions: The ORR for SCAI was significantly higher than that for LCBI. These data indicate that anti-PD-1/PD-L1 inhibitors could make tumors more vulnerable to subsequent chemotherapy. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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