Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Canceropen access
- Authors
- Cho, JH[Cho, Jong Ho]; Zhou, W[Zhou, Wei]; Choi, YL[Choi, Yoon-La]; Sun, JM[Sun, Jong-Mu]; Choi, H[Choi, Hyejoo]; Kim, TE[Kim, Tae-Eun]; Dolled-Filhart, M[Dolled-Filhart, Marisa]; Emancipator, K[Emancipator, Kenneth]; Rutkowski, MA[Rutkowski, Mary Anne]; Kim, J[Kim, Jhingook]
- Issue Date
- Jan-2018
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Programmed cell death 1 protein; Epidermal growth factor receptor; Non-small cell lung carcinoma
- Citation
- CANCER RESEARCH AND TREATMENT, v.50, no.1, pp.95 - 102
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 50
- Number
- 1
- Start Page
- 95
- End Page
- 102
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/21434
- DOI
- 10.4143/crt.2016.591
- ISSN
- 1598-2998
- Abstract
- Purpose Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Materials and Methods We retrospectively evaluated the relationship between PD-L1 expression and recurrencefree survival (RFS) and overall survival in 319 patients with EGFR-mutant NSCLC who were treated at Samsung Medical Center from 2006 to 2014. Membranous PD-L1 expression on tumor cells was measured using the PD-L1 IHC 22C3 pharmDx antibody and reported as tumor proportion score (TPS). Kaplan-Meier methods, log-rank test, and Cox proportional hazards models were used for survival analysis. Results All patients had >= 1 EGFR mutation-54% in exon 19 and 39% in exon 21. Overall, 51% of patients had PD-L1-positive tumors. The prevalence of PD-L1 positivity was higher among patients with stages II-IV versus stage I disease (64% vs. 44%) and among patients with other EGFR mutations (75%) than with L858R mutation (39%) or exon 19 deletion (52%). PD-L1 positivity was associated with shorter RFS, with an adjusted hazard ratio of 1.52 (95% confidence interval [CI], 0.81 to 2.84; median, 18 months) for the PD-L1 TPS >= 50% group, 1.51 (95% CI, 1.02 to 2.21; median, 31 months) for the PD-L1 TPS 1%-49% group, and 1.51 (95% CI, 1.05 to 2.18) for the combined PD-L1-positive groups (TPS >= 1%) compared with the PD-L1-negative group (median, 35 months). Conclusion PD-L1 expression is associated with disease stage and type of EGFR mutation. PD-L1 positivity might be associated with worse RFS among patients with surgically treated EGFRmutant NSCLC.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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