Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individualsopen access
- Authors
- Won, K.-B.[Won, K.-B.]; Han, D.[Han, D.]; Lee, J.H.[Lee, J.H.]; Lee, S.-E.[Lee, S.-E.]; Sung, J.M.[Sung, J.M.]; Choi, S.-Y.[Choi, S.-Y.]; Chun, E.J.[Chun, E.J.]; Park, S.H.[Park, S.H.]; Han, H.-W.[Han, H.-W.]; Sung, J.[Sung, J.]; Jung, H.O.[Jung, H.O.]; Chang, H.-J.[Chang, H.-J.]
- Issue Date
- 4-Jan-2018
- Publisher
- BioMed Central Ltd.
- Keywords
- Coronary artery calcification; Diabetes; Pre-diabetes
- Citation
- Cardiovascular Diabetology, v.17, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cardiovascular Diabetology
- Volume
- 17
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/21626
- DOI
- 10.1186/s12933-017-0653-0
- ISSN
- 1475-2840
- Abstract
- Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors. © The Author(s). 2018.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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