Recent progress and advances in stimuli-responsive polymers for cancer therapyopen access
- Authors
- Vijayakameswara Rao N.; Ko H.; Lee J.; Park J.H.
- Issue Date
- Aug-2018
- Publisher
- Frontiers Media S.A.
- Keywords
- Cancer therapy; Chemotherapy; Hypoxia; Light-triggered polymers; PH; Redox; ROS; Temperature-responsive polymers
- Citation
- Frontiers in Bioengineering and Biotechnology, v.6, no.AUG
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Bioengineering and Biotechnology
- Volume
- 6
- Number
- AUG
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/23897
- DOI
- 10.3389/fbioe.2018.00110
- ISSN
- 2296-4185
- Abstract
- The conventional chemotherapeutic agents, used for cancer chemotherapy, have major limitations including non-specificity, ubiquitous biodistribution, low concentration in tumor tissue, and systemic toxicity. In recent years, owing to their unique features, polymeric nanoparticles have been widely used for the target-specific delivery of drugs in the body. Although polymeric nanoparticles have addressed a number of important issues, the bioavailability of drugs at the disease site, and especially upon cellular internalization, remains a challenge. A polymer nanocarrier system with a stimuli-responsive property (e.g., pH, temperature, or redox potential), for example, would be amenable to address the intracellular delivery barriers by taking advantage of pH, temperature, or redox potentials. With a greater understanding of the difference between normal and pathological tissues, there is a highly promising role of stimuli-responsive nanocarriers for drug delivery in the future. In this review, we highlighted the recent advances in different types of stimuli-responsive polymers for drug delivery. © 2018 Rao, Ko, Lee and Park.
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Collections - Engineering > Chemical Engineering > 1. Journal Articles
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