Characteristics of adrenal incidentalomas in a large, prospective computed tomography-based multicenter study: The COAR study in Koreaopen accessCharacteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea
- Other Titles
- Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea
- Authors
- Ahn, S.H.[Ahn, S.H.]; Kim, J.H.[Kim, J.H.]; Baek, S.H.[Baek, S.H.]; Kim, H.[Kim, H.]; Cho, Y.Y.[Cho, Y.Y.]; Suh, S.[Suh, S.]; Kim, B.-J.[Kim, B.-J.]; Hong, S.[Hong, S.]; Koh, J.-M.[Koh, J.-M.]; Lee, S.H.[Lee, S.H.]; Song, K.-H.[Song, K.-H.]
- Issue Date
- Jun-2018
- Publisher
- Yonsei University College of Medicine
- Keywords
- Adrenal incidentaloma; Characteristics; Italy; Korea
- Citation
- Yonsei Medical Journal, v.59, no.4, pp.501 - 510
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Yonsei Medical Journal
- Volume
- 59
- Number
- 4
- Start Page
- 501
- End Page
- 510
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/24327
- DOI
- 10.3349/ymj.2018.59.4.501
- ISSN
- 0513-5796
- Abstract
- Purpose: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients and compared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniques and ethnicity differences. Materials and Methods: This was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients. Levels of plasma adrenocorticotrophic hormone, 24-h urinary free cortisol (UFC), serum cortisol after a 1 mg-dexamethasone suppression test, 24-h urinary fractionated metanephrine, and plasma aldosterone and plasma renin activity were measured. All AIs were characterized using computed tomography (CT). Results: Compared with the results of the Italian study, AIs in Korean patients were observed more frequently in men and predominantly on the left side. Korean patients with AIs were slightly younger, and fewer patients underwent surgery. Most AIs were nonfunctional in both studies, while fewer subclinical hypercortisolism and more primary aldosteronism (PA) cases were detected in Korean patients. In our study, high UFC levels showed very low sensitivity, compared to those in the Italian study. In pheo-chromocytoma or PA cases, there were no hormonal differences between the studies. AIs in Korean patients were smaller, such that a lower cutoff size for detecting adrenocortical carcinoma (ACC) could be warranted. Conclusion: Recent advances in CT technology were leveraged to provide accurate characteristics of AIs and to detect smaller ACCs. © Yonsei University College of Medicine 2018.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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