Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea
- Authors
- Lee, J.-H.[Lee, J.-H.]; Chon, S.[Chon, S.]; Cha, S.-A.[Cha, S.-A.]; Lim, S.-Y.[Lim, S.-Y.]; Kim, K.-R.[Kim, K.-R.]; Yun, J.-S.[Yun, J.-S.]; Rhee, S.Y.[Rhee, S.Y.]; Yoon, K.-H.[Yoon, K.-H.]; Ahn, Y.-B.[Ahn, Y.-B.]; Woo, J.-T.[Woo, J.-T.]; Ko, S.-H.[Ko, S.-H.]; Lee, M.-K.[Lee, M.-K.]; Park, K.S.[Park, K.S.]; Cha, B.S.[Cha, B.S.]; Baik, S.-H.[Baik, S.-H.]; Park, J.Y.[Park, J.Y.]; Lee, K.W.[Lee, K.W.]; Lee, I.-K.[Lee, I.-K.]; Park, T.S.[Park, T.S.]; Kim, I.J.[Kim, I.J.]; Cho, Y.J.[Cho, Y.J.]; Cho, D.H.[Cho, D.H.]; Chun, S.W.[Chun, S.W.]; Kim, S.H.[Kim, S.H.]; Sohn, S.Y.[Sohn, S.Y.]; Hwang, Y.C.[Hwang, Y.C.]; Kang, E.[Kang, E.]; Choi, J.[Choi, J.]; Korean Diabetes Prevention Study Investigators[Korean Diabetes Prevention Study Investigators]
- Issue Date
- Mar-2021
- Publisher
- Korean Association of Internal Medicine
- Keywords
- Diabetes mellitus; Hemoglobin A1C; Impaired fasting glucose; Overweight; Prediabetic state; Type 2
- Citation
- Korean Journal of Internal Medicine, v.36, no.2, pp.382 - 391
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Korean Journal of Internal Medicine
- Volume
- 36
- Number
- 2
- Start Page
- 382
- End Page
- 391
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/24991
- DOI
- 10.3904/KJIM.2019.171
- ISSN
- 1226-3303
- Abstract
- Background/Aims: We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea. Methods: Among the participants from the Korean Diabetes Prevention Study, individuals with FPG ≥ 100 mg/dL, body mass index (BMI) ≥ 23.0 kg/m2, and no previous history of T2DM were consecutively enrolled after a 75 g glucose tolerance test. We analyzed the differences in the clinical characteristics in subjects with stage 1 (FPG, 100 to 109 mg/dL) and stage 2 (FPG, 110 to 125 mg/dL) impaired fasting glucose (IFG). Results: Of 1,637 participants, 27.2% had T2DM and 59.3% had IFG and/or impaired glucose tolerance (IGT). The mean age was 55.0 ± 8.1 years and the mean BMI was 26.3 ± 2.7 kg/m2. Based on FPG criteria, 515 (31.4%) and 352 (21.5%) subjects were classified as having stage 1 and stage 2 IFG, respectively. The 19.0% of stage 1 and 43.5% of stage 2 subjects showed 2hr PG levels in the diabetic range. Even for those in the normal FPG range, 63 (9.5%) participants showed a 2hr PG level of ≥ 200 mg/dL. Of 446 subjects with newly-diagnosed diabetes, 340 (76.2%) showed FPG levels <; 126 mg/dL. Conclusions: The oral glucose tolerance test should be actively considered for Korean adults who are overweight or obese with the IFG range (FPG, 100 to 125 mg/dL) to allow for early detection of diabetes and prompt intervention. © 2021 The Korean Association of Internal Medicine.
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