Comprehensive Immuno-Molecular Profiles for Liposarcoma: Roles of Programmed Death Ligand 1, Microsatellite Instability, and PIK3CA
- Authors
- Jeon, HM[Jeon, Hyae Min]; Lee, JS[Lee, Jae Seok]; Kim, SH[Kim, Soo Hee]; Yun, KH[Yun, Kum-Hee]; Park, KH[Park, Kyu Hyun]; Jeon, MK[Jeon, Min Kyung]; Lee, YH[Lee, Young Han]; Yoon, HI[Yoon, Hong In]; Suh, JS[Suh, Jin-Suck]; Hur, H[Hur, Hyuk]; Kim, KS[Kim, Kyung Sik]; Kim, S[Kim, Sunghoon]; Kim, SH[Kim, Seung Hyun]; Kim, HS[Kim, Hyo Song]
- Issue Date
- Nov-2020
- Publisher
- KARGER
- Keywords
- Liposarcoma; Molecular subtypes; Programmed Death Ligand 1; Microsatellite instability; PIK3CA
- Citation
- ONCOLOGY, v.98, no.11, pp.817 - 826
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOLOGY
- Volume
- 98
- Number
- 11
- Start Page
- 817
- End Page
- 826
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/2667
- DOI
- 10.1159/000509004
- ISSN
- 0030-2414
- Abstract
- Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas who underwent curative resection were assessed for PD-L1 expression in the tumor and tumor-infiltrating lymphocytes (TILs), mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by immunohistochemistry, MSI using polymerase chain reaction, and PIK3CA mutation/amplification using pyrosequencing and fluorescence in situ hybridization. Results: Seventeen (23%) cases were TIL+ (>= 1 + expression) and associated with longer 5-year overall survival than those with TIL- tumors (84.4 vs. 60.8%, p = 0.007). Six (35.3%) PD-L1(+) tumors were detected only in TIL+ cases, with none detected in tumor cells. Two well-differentiated liposarcomas showed MSI, one low and one high with concurrent loss of MLH1, MSH6, and PMS2. PIK3CA mutation was detected in 7 (9.5%) [exon 9 (n = 4) and exon 20 (n = 3)] and only 1 Q546K mutation was a PD-L1(+) tumor. PIK3CA copy number gain was detected in 18 (24.4%) and was associated with TIL+ tumors (p = 0.045). Conclusions: Our comprehensive immuno-molecular panel suggests that liposarcoma should be categorized based on the molecular genomic subtype for precision medicine.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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