The impact of pathologic differentiation (well/poorly) and the degree of Ki-67 index in patients with metastatic WHO grade 3 GEP-NECsopen access
- Authors
- Kim, HK[Kim, Hee Kyung]; Ha, SY[Ha, Sang Yun]; Lee, J[Lee, Jeeyun]; Park, SH[Park, Se Hoon]; Park, JO[Park, Joon Oh]; Lim, HY[Lim, Ho Yeong]; Kang, WK[Kang, Won Ki]; Park, YS[Park, Young Suk]; Kim, ST[Kim, Seung Tae]
- Issue Date
- 26-Sep-2017
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- pathologic differentiation; Ki67 index; gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC)s
- Citation
- ONCOTARGET, v.8, no.43, pp.73974 - 73980
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 8
- Number
- 43
- Start Page
- 73974
- End Page
- 73980
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/27272
- DOI
- 10.18632/oncotarget.18168
- ISSN
- 1949-2553
- Abstract
- We investigated the impact of pathologic differentiation (well or poorly differentiated) in metastatic grade 3 GEP-NEC patients receiving etoposide and platinum (EP)-based therapy, and evaluated a more exact Ki67 index cut-off point to select patients with grade 3 GEP-NEC who might benefit from EP-based therapy. A total of 31 patients with metastatic grade 3 GEP-NECs receiving EP-based therapy were included in this study. Primary sites included 13 foregut-derived GEP-NECs [stomach (n = 4), duodenum (n = 4), and pancreas (n = 5)] and 2 hindgut-derived GEP-NECs of the rectum. 14 patients had well differentiated (WD) and 17 had poorly differentiated (PD). Between WD and PD grade 3 GEP-NECs, there was a significant difference in the distribution of Ki67 index. There was no significant difference of treatment efficacy between WD and PD grade 3 GEP-NECs (RR; 35.7% vs. 41.2%, p = 0.525). Tumor response to EP occurred in 5 of 7 patients with Ki67 > 60% and 7 of 24 with Ki67 <= 60%, which was significantly different (RR; 71.4% vs. 29.2%, P = 0.043). Among grade 3 GEP-NECs, there was a significant difference in ranges of Ki67 index between WD and PD NECs. Higher levels (> 60%) of Ki67 index might be a predictive marker for efficacy of EP as a standard regimen in grade 3 GEP-NECs.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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