Cytotoxic effect of sanguiin H-6 on MCF-7 and MDA-MB-231 human breast carcinoma cells
- Authors
- Park, EJ[Park, Eun-Ji]; Lee, D[Lee, Dahae]; Baek, SE[Baek, Seon-Eun]; Kim, KH[Kim, Ki Hyun]; Kang, KS[Kang, Ki Sung]; Jang, TS[Jang, Tae Su]; Lee, HL[Lee, Hye Lim]; Song, JH[Song, Ji Hoon]; Yoo, JE[Yoo, Jeong-Eun]
- Issue Date
- 15-Sep-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Sanguiin H-6; Apoptosis; Estrogen receptor; MCF-7 cells; MDA-MB-231 cells
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.18, pp.4389 - 4392
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 18
- Start Page
- 4389
- End Page
- 4392
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/27311
- DOI
- 10.1016/j.bmcl.2017.08.019
- ISSN
- 0960-894X
- Abstract
- Sanguiin H-6 is a dimer of casuarictin linked by a bond between the gallic acid residue and one of the hexahydroxydiphenic acid units. It is an effective compound extracted from Rubus coreanus. It has an anticancer effect against several human cancer cells; however, its effect on breast cancer cells has not been clearly demonstrated. Thus, we aimed to investigate the anticancer effect and mechanism of action of sanguiin H-6 against two human breast carcinoma cell lines (MCF-7 and MDA-MB-231). We found that sanguiin H-6 significantly reduced cell viability in a concentration-dependent manner. It also increased the rates at which MCF-7 and MDA-MB-231 cells underwent apoptosis. Furthermore, sanguiin H-6 induced the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, which resulted in apoptosis. However, cleavage of caspase-9 was only detectable in MCF-7 cells. In addition, sanguiin H-6 increased the ratio of Bax to Bcl-2 in both MCF-7 and MDA-MB-231 cells. These findings suggest that sanguiin H-6 is a potent therapeutic agent against breast cancer cells. In addition, it exerts its anticancer effect in an estrogen-receptor-independent manner. (C) 2017 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.