Preservation of the endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound ablation of submucosal uterine fibroids
- Authors
- Kim, YS[Kim, Young-sun]; Kim, TJ[Kim, Tae-Joong]; Lim, HK[Lim, Hyo Keun]; Rhim, H[Rhim, Hyunchul]; Jung, SH[Jung, Sin-Ho]; Ahn, JH[Ahn, Joong Hyun]; Lee, JW[Lee, Jeong-Won]; Kim, BG[Kim, Byoung-Gie]
- Issue Date
- Sep-2017
- Publisher
- SPRINGER
- Keywords
- Uterine fibroid; High-intensity focused ultrasound ablation; Magnetic resonance imaging; Endometrium; Safety
- Citation
- EUROPEAN RADIOLOGY, v.27, no.9, pp.3956 - 3965
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 27
- Number
- 9
- Start Page
- 3956
- End Page
- 3965
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/27754
- DOI
- 10.1007/s00330-017-4765-4
- ISSN
- 0938-7994
- Abstract
- To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. In total, 117 submucosal fibroids (diameter: 5.9 +/- 3.0 cm) in 101 women (age: 43.6 +/- 4.4 years) treated with MR-HIFU ablation were retrospectively analysed. Endometrial integrity was assessed with contrast-enhanced T1-weighted images at immediate (n = 101), 3-month (n = 62) and 12-month (n = 15) follow-ups. Endometrial impairment was classified into grades 0 (continuous endometrium), 1 (pin-point, full-thickness discontinuity), 2 (between grade 1 and 3), or 3 (full-thickness discontinuity > 1 cm). Risk factors were assessed with generalized estimating equation (GEE) analysis. Among 117 fibroids, grades 0, 1, 2 and 3 endometrial impairments were observed at initial examination in 56.4%, 24.8%, 13.7% and 4.3%, respectively. Among 37 fibroid cases of endometrial impairment for which follow-ups were conducted, 30 showed improvements at 3- and/or 12-month follow-up. GEE analysis revealed the degree of endometrial protrusion was significantly associated with severity of endometrial injury (P < 0.0001). After MR-HIFU ablation of submucosal fibroids, endometrial enhancement was preserved intact or minimally impaired in most cases. Impaired endometrium, which is more common after treating endometrially-protruded fibroids, may recover spontaneously.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
- Samsung Advanced Institute for Health Sciences and Technology, SKKU > Samsung Advanced Institute for Health Sciences and Technology, SKKU > 1. Journal Articles
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