Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infectionsopen access
- Authors
- Jeong, S.H.[Jeong, S.H.]; Kim, S.-Y.[ Kim, S.-Y.]; Huh, H.J.[ Huh, H.J.]; Ki, C.-S.[Ki, C.-S.]; Lee, N.Y.[Lee, N.Y.]; Kang, C.-I.[Kang, C.-I.]; Chung, D.R.[Chung, D.R.]; Peck, K.R.[Peck, K.R.]; Shin, S.J.[ Shin, S.J.]; Koh, W.-J.[Koh, W.-J.]
- Issue Date
- Jul-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Non-tuberculous mycobacteria; Mycobacterium abscessus; Mycobacterium massiliense; Macrolides; Drug resistance
- Citation
- INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.60, pp.49 - 56
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Volume
- 60
- Start Page
- 49
- End Page
- 56
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/28347
- DOI
- 10.1016/j.ijid.2017.05.007
- ISSN
- 1201-9712
- Abstract
- Objectives: The differentiation between Mycobacterium abscessus subspecies abscessus (M. abscessus) and Mycobacterium abscessus subspecies massiliense (M. massiliense) and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patients with Mycobacterium abscessus complex (MABC) infections. Unlike pulmonary MABC infections, little information on extrapulmonary MABC infections is available. Methods: The molecular identification of clinical isolates was performed, and the clinical characteristics and treatment outcomes of 20 consecutive patients with extrapulmonary MABC infections were assessed. Results: M. abscessus and M. massiliense each caused 10 (50%) of the cases. Eight (80%) M. abscessus isolates that had inducible resistance to clarithromycin harbored an intact erm( 41) gene of the T28 variant, whereas two (20%) M. abscessus isolates had the C28 erm(41) variant and were susceptible to clarithromycin. All M. massiliense isolates had a truncated erm(41) gene and were susceptible to clarithromycin. The drug susceptibility profiles other than clarithromycin were similar for the M. abscessus and M. massiliense isolates. Of the 20 patients, 17 (85%) showed a favorable outcome, including all patients with M. massiliense infection and 70% (7/10) of patients with M. abscessus infection. Favorable outcomes were associated with M. massiliense and M. abscessus isolates with a non-functional erm(41) gene (p = 0.049). Conclusions: Precise species and subspecies identification and the determination of macrolide susceptibility are recommended for the optimal treatment of extrapulmonary MABC infections. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.