Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal AtrophyPrognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy
- Other Titles
- Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy
- Authors
- Lee, JS[Lee, Jin San]; Jung, NY[Jung, Na-Yeon]; Jang, YK[Jang, Young Kyoung]; Kim, HJ[Kim, Hee Jin]; Seo, SW[Seo, Sang Won]; Lee, J[Lee, Juyoun]; Kim, YJ[Kim, Yeo Jin]; Lee, JH[Lee, Jae-Hong]; Kim, BC[Kim, Byeong C.]; Park, KW[Park, Kyung-Won]; Yoon, SJ[Yoon, Soo Jin]; Jeong, JH[Jeong, Jee H.]; Kim, SY[Kim, Sang Yun]; Kim, SH[Kim, Seung Hyun]; Kim, EJ[Kim, Eun-Joo]; Park, KC[Park, Key-Chung]; Knopman, DS[Knopman, David S.]; Na, DL[Na, Duk L.]
- Issue Date
- Jul-2017
- Publisher
- KOREAN NEUROLOGICAL ASSOC
- Keywords
- frontotemporal dementia; frontotemporal lobar degeneration; magnetic resonance imaging; prognosis
- Citation
- JOURNAL OF CLINICAL NEUROLOGY, v.13, no.3, pp.234 - 242
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF CLINICAL NEUROLOGY
- Volume
- 13
- Number
- 3
- Start Page
- 234
- End Page
- 242
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/28395
- DOI
- 10.3988/jcn.2017.13.3.234
- ISSN
- 1738-6586
- Abstract
- Background and Purpose Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy(F-type). Methods In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D-and F-types. Survival analyses were performed for 62 of the 74 patients. Results While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy. Conclusions The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type maybe associated with the earlier appearance of motor symptoms.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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