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Mutation of MED12 is not a frequent occurrence in, prostate cancer of Korean patientsopen access
- Authors
- Yoon, N[Yoon, Nara]; Lim, S[Lim, Sharon]; Kang, SY[Kang, So Young]; Kwon, GY[Kwon, Ghee Young]; Jeon, HG[Jeon, Hwang Gyun]; Jeong, BC[Jeong, Byong Chang]; Seo, SI[Seo, Seong Il]; Jeon, SS[Jeon, Seong Soo]; Lee, HM[Lee, Hyun Moo]; Choi, HY[Choi, Han Yong]
- Issue Date
- May-2017
- Publisher
- MEDKNOW PUBLICATIONS & MEDIA PVT LTD
- Keywords
- mediator complex subunit 12; mutation analysis; prostate cancer; prostate neoplasms
- Citation
- ASIAN JOURNAL OF ANDROLOGY, v.19, no.3, pp.346 - 349
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN JOURNAL OF ANDROLOGY
- Volume
- 19
- Number
- 3
- Start Page
- 346
- End Page
- 349
- ISSN
- 1008-682X
- Abstract
- Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional "gold standard".
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