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Empagliflozin and Cardiovascular Outcomes in Asian Patients With Type 2 Diabetes and Established Cardiovascular Disease - Results From EMPA-REG OUTCOME (R)
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- Kaku, K[Kaku, Kohei]; Lee, J[Lee, Jisoo]; Mattheus, M[Mattheus, Michaela]; Kaspers, S[Kaspers, Stefan]; George, J[George, Jyothis]; Woerle, HJ[Woerle, Hans-Juergen]; Aizenberg, D[Aizenberg, D.]; Ulla, M[Ulla, M.]; Waitman, J[Waitman, J.]; De Loredo, L[De Loredo, L.]; Farias, J[Farias, J.]; Fideleff, H[Fideleff, H.]; Lagrutta, M[Lagrutta, M.]; Maldonado, N[Maldonado, N.]; Colombo, H[Colombo, H.]; Pacora, FF[Ferre Pacora, F.]; Wasserman, A[Wasserman, A.]; Maffei, L[Maffei, L.]; Lehman, R[Lehman, R.]; Selvanayagam, J[Selvanayagam, J.]; d'Emden, M[d'Emden, M.]; Fasching, P[Fasching, P.]; Paulweber, B[Paulweber, B.]; Toplak, H[Toplak, H.]; Luger, A[Luger, A.]; Drexel, H[Drexel, H.]; Prager, R[Prager, R.]; Schnack, C[Schnack, C.]; Schernthaner, G[Schernthaner, G.]; Fliesser-Gorzer, E[Fliesser-Goerzer, E.]; Kaser, S[Kaser, S.]; Scheen, A[Scheen, A.]; Van Gaal, L[Van Gaal, L.]; Hollanders, G[Hollanders, G.]; Kockaerts, Y[Kockaerts, Y.]; Capiau, L[Capiau, L.]; Chachati, A[Chachati, A.]; Persu, A[Persu, A.]; Hermans, M[Hermans, M.]; Vantroyen, D[Vantroyen, D.]; Vercammen, C[Vercammen, C.]; Van de Borne, P[Van de Borne, P.]; Mathieu, C[Mathieu, C.]; Benhalima, K[Benhalima, K.]; Lienart, F[Lienart, F.]; Mortelmans, J[Mortelmans, J.]; Strivay, M[Strivay, M.]; Vereecken, G[Vereecken, G.]; Keymeulen, B[Keymeulen, B.]; Lamkanfi, F[Lamkanfi, F.]; Chacra, A[Chacra, A.]; Eliaschewitz, F[Eliaschewitz, F.]; Zanella, M[Zanella, M.]; Faludi, A[Faludi, A.]; Bertolami, M[Bertolami, M.]; Hayashida, C[Hayashida, C.]; Salles, JN[Nunes Salles, J.]; Monte, O[Monte, O.]; Dinato, M[Dinato, M.]; Manenti, E[Manenti, E.]; Rassi, N[Rassi, N.]; Halpern, A[Halpern, A.]; Lima, M[Lima Filho, M.]; Ayoub, J[Ayoub, J.]; Felicio, J[Felicio, J.]; Borges, J[Borges, J.]; Gross, J[Gross, J.]; Sgarbi, J[Sgarbi, J.]; Betti, R[Betti, R.]; Tiburcio, A[Tiburcio, A.]; Purisch, S[Purisch, S.]; Schmid, H[Schmid, H.]; Takahashi, M[Takahashi, M.]; Castro, M[Castro, M.]; Rea, R[Rea, R.]; Hissa, M[Hissa, M.]; Neto, BG[Geloneze Neto, B.]; Saraiva, J[Saraiva, J.]; Henein, S[Henein, S.]; Lochnan, H[Lochnan, H.]; Imran, SA[Imran, S. A.]; Clayton, D[Clayton, D.]; Bayly, K[Bayly, K.]; Berlingieri, J[Berlingieri, J.]; Boucher, P[Boucher, P.]; Chan, Y[Chan, Y.]; Gupta, M[Gupta, M.]; Chehayeb, R[Chehayeb, R.]; Ouellett, A[Ouellett, A.]; Ur, E[Ur, E.]; Woo, V[Woo, V.]; Zinman, B[Zinman, B.]; St Amour, E[St Amour, E.]; Lozano, MT[Terront Lozano, M.]; Lozno, HY[Yupanqui Lozno, H.]; Urina, M[Urina, M.]; Jaramillo, PL[Lopez Jaramillo, P.]; Jaramillo, N[Jaramillo, N.]; Sanchez, G[Sanchez, G.]; Perez, G[Perez, G.]; Tusek, S[Tusek, S.]; Mirosevic, G[Mirosevic, G.]; Goldoni, V[Goldoni, V.]; Jurisic-Erzen, D[Jurisic-Erzen, D.]; Balasko, A[Balasko, A.]; Balic, S[Balic, S.]; Drvodelic-Sunic, E[Drvodelic-Sunic, E.]; Varzic, SC[Varzic, S. Canecki]; Machkova, M[Machkova, M.]; Weiner, P[Weiner, P.]; Lastuvka, J[Lastuvka, J.]; Olsovsky, J[Olsovsky, J.]; Krarup, T[Krarup, T.]; Ridderstrale, M[Ridderstrale, M.]; Tarnow, L[Tarnow, L.]; Boesgaard, TW[Boesgaard, T. Wellov]; Lihn, AS[Lihn, A. Saetre]; Christensen, P[Christensen, P.]; Juhl, H[Juhl, H.]; Urhammer, S[Urhammer, S.]; Lund, P[Lund, P.]; Adojaan, B[Adojaan, B.]; Jakovlev, U[Jakovlev, U.]; Lanno, R[Lanno, R.]; Lubi, M[Lubi, M.]; Marandi, T[Marandi, T.]; Gouet, D[Gouet, D.]; Courreges, J[Courreges, J.]; Zaoui, P[Zaoui, P.]; Choukroun, G[Choukroun, G.]; Petit, C[Petit, C.]; Formagne, L[Formagne, L.]; Estour, B[Estour, B.]; Mabire, P[Mabire, P.]; Daugenet, C[Daugenet, C.]; Lemarie, B[Lemarie, B.]; Clavel, S[Clavel, S.]; Aure, P[Aure, P.]; Remaud, P[Remaud, P.]; Halimi, J[Halimi, J.]; Hadjadj, S[Hadjadj, S.]; Couffinhal, T[Couffinhal, T.]; Glonti, S[Glonti, S.]; Metreveli, D[Metreveli, D.]; Lominadze, Z[Lominadze, Z.]; Giorgadze, E[Giorgadze, E.]; Burtchuladze, T[Burtchuladze, T.]; Javashvili, L[Javashvili, L.]; Kurashvili, G[Kurashvili, G.]; Kurashvili, R[Kurashvili, R.]; Virsaladze, D[Virsaladze, D.]; Nadareishvili, L[Nadareishvili, L.]; Khomasuridze, A[Khomasuridze, A.]; Cahill, T[Cahill, T.]; Green, F[Green, F.]; MacRury, S[MacRury, S.]; Waldron, M[Waldron, M.]; Middleton, A[Middleton, A.]; McKnight, J[McKnight, J.]; Pearson, E[Pearson, E.]; Butler, M[Butler, M.]; Choksi, M[Choksi, M.]; Caldwell, I[Caldwell, I.]; Farmer, I[Farmer, I.]; Wyatt, N[Wyatt, N.]; Patrick, J[Patrick, J.]; O'Brien, I[O'Brien, I.]; Devers, M[Devers, M.]; Bousboulas, S[Bousboulas, S.]; Pappas, S[Pappas, S.]; Piaditis, G[Piaditis, G.]; Vryonidou, A[Vryonidou, A.]; Tentolouris, N[Tentolouris, N.]; Karamitsos, K[Karamitsos, K.]; Manes, C[Manes, C.]; Benroubi, M[Benroubi, M.]; Avramidis, I[Avramidis, I.]; Ozaki, R[Ozaki, R.]; Tan, K[Tan, K.]; Siu, S[Siu, S.]; Tsang, C[Tsang, C.]; Dudas, M[Dudas, M.]; Nagy, K[Nagy, K.]; Salamon, C[Salamon, C.]; Ip, T[Ip, T.]; Geroo, L[Geroo, L.]; Patkay, J[Patkay, J.]; Tabak, A[Tabak, A.]; Juhasz, F[Juhasz, F.]; Szentpeteri, I[Szentpeteri, I.]; Tamas, G[Tamas, G.]; Ghaisas, N[Ghaisas, N.]; Bantwal, G[Bantwal, G.]; Mohan, V[Mohan, V.]; Gupta, J[Gupta, J.]; Sadhu, N[Sadhu, N.]; Kulkarni, A[Kulkarni, A.]; Garg, N[Garg, N.]; Reddy, S[Reddy, S.]; Deshpande, N[Deshpande, N.]; Gutlapalli, K[Gutlapalli, K.]; Pillai, M[Pillai, M.]; Premchand, R[Premchand, R.]; Badgandi, M[Badgandi, M.]; Jain, S[Jain, S.]; Aravind, S[Aravind, S.]; Shamanna, P[Shamanna, P.]; Pandey, A[Pandey, A.]; Gupta, S[Gupta, S.]; Pramono, B[Pramono, B.]; Saksono, HD[Saksono, H. Dante]; Agung, P[Agung, P.]; Wahono, SD[Wahono, S. Djoko]; Suastika, K[Suastika, K.]; Tanggo, Y[Tanggo, Y.]; Juwana, Y[Juwana, Y.]; Siswanto, B[Siswanto, B.]; Adawi, F[Adawi, F.]; Efrati, S[Efrati, S.]; Mazen, E[Mazen, E.]; Bashkin, A[Bashkin, A.]; Herskovits, T[Herskovits, T.]; Jaffe, A[Jaffe, A.]; Schiff, E[Schiff, E.]; Wainstein, J[Wainstein, J.]; Taddei, S[Taddei, S.]; Aiello, A[Aiello, A.]; Arca, M[Arca, M.]; Calabro, P[Calabro, P.]; Cignarelli, M[Cignarelli, M.]; Fioretto, P[Fioretto, P.]; Reggiani, GM[Reggiani, G. Marchesini]; Gnasso, A[Gnasso, A.]; Marchionni, N[Marchionni, N.]; Marsilii, A[Marsilii, A.]; Bucci, M[Bucci, M.]; Mezzetti, A[Mezzetti, A.]; Pozzilli, P[Pozzilli, P.]; Colivicchi, F[Colivicchi, F.]; Santini, M[Santini, M.]; Moro, E[Moro, E.]; Toscano, V[Toscano, V.]; Fucili, A[Fucili, A.]; Semplicini, A[Semplicini, A.]; Monno, S[Monno, S.]; Furui, K[Furui, K.]; Higashiue, S[Higashiue, S.]; Hiramatsu, N[Hiramatsu, N.]; Kawamitsu, K[Kawamitsu, K.]; Takenaka, T[Takenaka, T.]; Takahashi, H[Takahashi, H.]; Hojo, F[Hojo, F.]; Onishi, Y[Onishi, Y.]; Izumino, K[Izumino, K.]; Okubo, M[Okubo, M.]; Wakida, Y[Wakida, Y.]; Kondo, Y[Kondo, Y.]; Hieshima, K[Hieshima, K.]; Jinnouchi, H[Jinnouchi, H.]; Suzuki, A[Suzuki, A.]; Ito, M[Ito, M.]; Park, S[Park, S.]; Kim, Y[Kim, Y.]; Hong, T[Hong, T.]; Park, H[Park, H.]; Gwon, H[Gwon, H.]; Kim, H[Kim, H.]; Kang, K[Kang, K.]; Jeong, M[Jeong, M.]; Seung, K[Seung, K.]; Lim, D[Lim, D.]; Rha, S[Rha, S.]; Tahk, S[Tahk, S.]; Yang, J[Yang, J.]; Yoon, J[Yoon, J.]; Shin, M[Shin, M.]; Kim, D[Kim, D.]; Jeong, J[Jeong, J.]; Ahmad, NN[Ahmad, N. 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- Issue Date
- Feb-2017
- Publisher
- JAPANESE CIRCULATION SOC
- Keywords
- Diabetes mellitus; Mortality; Race; Sodium-glucose cotransporter 2; Treatment outcomes
- Citation
- CIRCULATION JOURNAL, v.81, no.2, pp.227 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- CIRCULATION JOURNAL
- Volume
- 81
- Number
- 2
- Start Page
- 227
- End Page
- +
- ISSN
- 1346-9843
- Abstract
- Background: In the EMPA-REG OUTCOME (R) trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular (CV) events (3-point MACE: composite of CV death, non-fatal myocardial infarction, or non-fatal stroke) by 14%, CV death by 38%, hospitalization for heart failure by 35%, and all-cause mortality by 32% in patients with type 2 diabetes (T2DM) and established CV disease. We investigated the effects of empagliflozin in patients of Asian race. Methods and Results: Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo. Of 7,020 patients treated, 1,517 (21.6%) were of Asian race. The reduction in 3-point MACE in Asian patients was consistent with the overall population: 3-point MACE occurred in 79/1,006 patients (7.9%) in the pooled empagliflozin group vs. 58/511 patients (11.4%) in the placebo group (hazard ratio: 0.68 [95% confidence interval: 0.48-0.95], P-value for treatment by race interaction (Asian, White, Black/African-American): 0.0872). The effects of empagliflozin on the components of MACE, all-cause mortality, and heart failure outcomes in Asian patients were consistent with the overall population (P-values for interaction by race >0.05). The adverse event profile of empagliflozin in Asian patients was similar to the overall trial population. Conclusions: Reductions in the risk of CV outcomes and mortality with empagliflozin in Asian patients with T2DM and established CV disease were consistent with the overall trial population.
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Related Researcher
- GWON, HYEON CHEOL
- Medicine (Medicine)