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Down-regulation of diesel particulate matter-induced airway inflammation by the PDZ motif peptide of ZO-1
- Authors
- Kang, DH[Kang, Dong Hee]; Lee, TJ[Lee, Tae-Jin]; Kim, JW[Kim, Ji Wook]; Shin, YS[Shin, Yu Som]; Kim, JD[Kim, Ju Deok]; Ryu, SW[Ryu, Sung Won]; Ryu, S[Ryu, Siejeong]; Choi, YH[Choi, Yung Hyun]; Kim, CH[Kim, Cheol Hong]; You, E[You, EunAe]; Rhee, S[Rhee, SangMyung]; Song, KS[Song, Kyoung Seob]
- Issue Date
- Oct-2020
- Publisher
- WILEY
- Keywords
- airway inflammation; PDZ domain; PM2; 5; RGS12; ZO-1
- Citation
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.24, no.20, pp.12211 - 12218
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Volume
- 24
- Number
- 20
- Start Page
- 12211
- End Page
- 12218
- ISSN
- 1582-1838
- Abstract
- Although diesel airborne particulate matter (PM2.5) has been known to play a role in many human diseases, there is no direct evidence that therapeutic drugs or proteins can diminish PM2.5-induced diseases. Nevertheless, studies examining the negative control mechanisms of PM2.5-induced diseases are critical to develop novel therapeutic medications. In this study, the consensus PDZ peptide of ZO-1 inhibited PM2.5-induced inflammatory cell infiltration, pro-inflammatory cytokine gene expression, and TEER in bronchoalveolar lavage (BAL) fluid and AM cells. Our data indicated that the PDZ domain in ZO-1 is critical for regulation of the PM2.5-induced inflammatory microenvironment. Therefore, the PDZ peptide may be a potential therapeutic candidate during PM-induced respiratory diseases.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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