Supraclavicular and/or celiac lymph node metastases from thoracic esophageal squamous cell carcinoma did not compromise survival following neoadjuvant chemoradiotherapy and surgeryopen access
- Authors
- Cho, W.K.[Cho, W.K.]; Oh, D.[ Oh, D.]; Ahn, Y.C.[Ahn, Y.C.]; Shim, Y.M.[Shim, Y.M.]; Zo, J.I.[Zo, J.I.]; Sun, J.-M.[Sun, J.-M.]; Ahn, M.-J.[Ahn, M.-J.]; Park, K.[Park, K.]
- Issue Date
- 10-Jan-2017
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- Celiac lymph node; Esophageal cancer; Neoadjuvant chemoradiotherapy; Staging; Supraclavicular lymph node
- Citation
- ONCOTARGET, v.8, no.2, pp.3542 - 3552
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 8
- Number
- 2
- Start Page
- 3542
- End Page
- 3552
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/30513
- DOI
- 10.18632/oncotarget.12200
- ISSN
- 1949-2553
- Abstract
- This study is to evaluate the prognostic significance of supraclavicular and/or celiac lymph node (LN) metastases in locally advanced thoracic esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (NACRT) and surgery. Among the total 199 patients, 75 (37.7%) had supraclavicular and/or celiac LN metastasis. Surgery was performed following NACRT in 168 patients (84.4%). After the median 18.7 (1.0-147.2) months' follow-up, 2-year rates of progressionfree survival (PFS) and overall survival (OS) in all patients were 48.1% and 65.7%, respectively. In multivariate analyses, negative surgical margin (p < 0.001), ypT0 stage (p = 0.004), and ypN0 stage (p = 0.020) were significantly favorable factors for PFS, and negative surgical margin (p < 0.001) was the only significantly favorable factor for OS. Metastasis to the supraclavicular and/or celiac LNs was significant factor neither for PFS (p = 0.311) nor OS (p = 0.515). Supraclavicular and/or celiac LN metastasis did not compromise the clinical outcomes following NACRT and surgery.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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