Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
- Authors
- Duc, N.M.[Duc, N.M.]; Kim, H.R.[Kim, H.R.]; Chung, K.Y.[Chung, K.Y.]
- Issue Date
- 1-Jan-2017
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Dynamics; G protein; G protein-coupled receptor; Structure
- Citation
- BIOMOLECULES & THERAPEUTICS, v.25, no.1, pp.4 - 11
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 25
- Number
- 1
- Start Page
- 4
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/30546
- DOI
- 10.4062/biomolther.2016.169
- ISSN
- 1976-9148
- Abstract
- Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the beta 2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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