The Control of Drug Release and Vascular Endothelialization after Hyaluronic Acid-Coated Paclitaxel Multi-Layer Coating Stent Implantation in Porcine Coronary Restenosis Model
- Authors
- Bae, I.-H.[Bae, I.-H.]; Jeong, M.H.[ Jeong, M.H.]; Kim, J.H.[ Kim, J.H.]; Park, Y.H.[Park, Y.H.]; Lim, K.S.[ Lim, K.S.]; Park, D.S.[ Park, D.S.]; Shim, J.W.[ Shim, J.W.]; Kim, J.H.[ Kim, J.H.]; Ahn, Y.[ Ahn, Y.]; Hong, Y.J.[ Hong, Y.J.]; Sim, D.S.[ Sim, D.S.]
- Issue Date
- Jan-2017
- Publisher
- KOREAN SOC CARDIOLOGY
- Keywords
- Coronary restenosis; Hyaluronic acid; Paclitaxel; Preclinical drug evaluation; Stents
- Citation
- KOREAN CIRCULATION JOURNAL, v.47, no.1, pp.123 - 131
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN CIRCULATION JOURNAL
- Volume
- 47
- Number
- 1
- Start Page
- 123
- End Page
- 131
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/30791
- DOI
- 10.4070/kcj.2016.0203
- ISSN
- 1738-5520
- Abstract
- Background and Objectives: Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not acidify the local environment. The aim of this study was to fabricate an HA-coated paclitaxel (PTX)-eluting stent via simple ionic interactions and to evaluate its effects in vitro and in vivo. Materials and Methods: HA and catechol were conjugated by means of an activation agent, and then the stent was immersed in this solution (resulting in a HA-coated stent). After that, PTX was immobilized on the HA-coated stent (resulting in a hyaluronic acid-coated paclitaxel-eluting stent [H-PTX stent]). Study groups were divided into 4 groups: bare metal stent (BMS), HA, H-PTX, and poly (L-lactide)coated paclitaxel-eluting stent (P-PTX). Stents were randomly implanted in a porcine coronary artery. After 4 weeks, vessels surrounding the stents were isolated and subjected to various analyses. Results: Smoothness of the surface was maintained after expansion of the stent. In contrast to a previous study on a PTX-eluting stent, in this study, the PTX was effectively released up to 14 days (a half amount of PTX in 4 days). The proliferation of smooth muscle cells was successfully inhibited (by 80.5+12.110/o at 7 days of culture as compared to the control) by PTX released from the stent. Animal experiments showed that the H-PTX stent does not induce an obvious inflammatory response. Nevertheless, restenosis was clearly decreased in the H-PTX stent group (9.8+3.25%) compared to the bare-metal stent group (29.7+8.11%). Conclusion: A stent was stably coated with P-D( via simple ionic interactions with HA. Restenosis was decreased in the H-PTX group. These results suggest that HA, a natural polymer, is suitable for fabrication of drug-eluting stents (without inflammation) as an alternative to a synthetic polymer.
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