고강도 인터벌 트레이닝이 D-Gal/LPS로 유도된 마우스의 급성 간 부전에 미치는 효과open accessEffect of High-Intensity Interval Training on Acute Liver Failure Induced by D-Galactosamine/Lipopolysaccharide in Balb/c Mice
- Other Titles
- Effect of High-Intensity Interval Training on Acute Liver Failure Induced by D-Galactosamine/Lipopolysaccharide in Balb/c Mice
- Authors
- 조진경[조진경]; 박수현[박수현]; 강현식[강현식]
- Issue Date
- 2017
- Publisher
- 한국운동생리학회
- Keywords
- 급성 간 부전; LPS; 염증; 고강도 인터벌 트레이닝; Acute liver failure; LPS; Inflammation; High-intensity interval training
- Citation
- 운동과학, v.26, no.3, pp.223 - 228
- Indexed
- KCI
- Journal Title
- 운동과학
- Volume
- 26
- Number
- 3
- Start Page
- 223
- End Page
- 228
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/32090
- DOI
- 10.15857/ksep.2017.26.3.223
- ISSN
- 1226-1726
- Abstract
- PURPOSE: This study investigated the protective role of high-intensity interval training against acute liver injury induced by D-galactosamine (D-Gal)/lipopolysaccharide (LPS).
METHODS: A total of 30 male BALB/c mice aged 5-week were randomly assigned to high-intensity, interval training group (EX, n=10) or control group in cage (Non-EX, n=20) for 10 weeks. Peritoneal injection of D-Gal (700 mg/kg body weight) and LPS (10 μg/kg body weight) was applied to induce acute liver injury, and liver tissue was harvested 6 h after the injection. Hematoxylin and Eosin (H&E) staining was used for liver histology. Real-time PCR was used to quantify expression of pro-inflammatory and anti-inflammatory genes in the liver.
RESULTS: The liver histology showed that D-Gal/LPS treatment resulted in hepatic damage and increased number of neutrophils in conjunction with upregulation of hepatic IL-6 and TNF-α mRNAs and downregulation of hepatic PPARα and SIRT1 mRNAs. On the other hand, the 10-week interval training resulted in a significant improvement in cardiorespiratory fitness assessed as run time to exhaustion on a treadmill. In addition, the interval training attenuated the D-Gal/LPS-induced liver damage and increased number of neutrophil in conjunction with downregulation of hepatic IL-6 and TNF-α mRNAs and upregulation of hepatic PPARα and SIRT1 mRNAs.
CONCLUSIONS: This study suggests that high-intensity interval training suppresses the D-Gal and LPS-induced acute liver damage and inflammatory responses.
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Collections - Sport Science > Department of Sport Science > 1. Journal Articles
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